Evidence map›Paper›PMID 37446065›Full record

ArticleInternational journal of molecular sciences2023

Visceral Obesity and Cytokeratin-18 Antigens as Early Biomarkers of Liver Damage.

Giulia de Alteriis, Gabriella Pugliese, Antonella Di Sarno, Giovanna Muscogiuri, Luigi Barrea, Valentina Cossiga, Giuseppe Perruolo, Michele Francesco Di Tolla, Francesca Zumbolo, Pietro Formisano and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Giulia de AlteriisEndocrinology Unit, Department of Clinical Medicine and Surgery, University of Naples "Federico II", Via Sergio Pansini 5, 80131 Naples, Italy.
Gabriella PuglieseEndocrinology Unit, Department of Clinical Medicine and Surgery, University of Naples "Federico II", Via Sergio Pansini 5, 80131 Naples, Italy.
Antonella Di SarnoEndocrinology Unit, Department of Clinical Medicine and Surgery, University of Naples "Federico II", Via Sergio Pansini 5, 80131 Naples, Italy.
Giovanna MuscogiuriEndocrinology Unit, Department of Clinical Medicine and Surgery, University of Naples "Federico II", Via Sergio Pansini 5, 80131 Naples, Italy.
Luigi BarreaDepartment of Humanities, Telematic University Pegaso, 80143 Naples, Italy.ORCID 0000-0001-9054-456X
Valentina CossigaDiseases of the Liver and Biliary System Unit, Department of Clinical Medicine and Surgery, University of Naples "Federico II", 80131 Naples, Italy.ORCID 0000-0002-0000-1076
Giuseppe PerruoloDepartment of Translational Medical Science, University of Naples "Federico II", 80131 Naples, Italy.ORCID 0000-0003-0479-8729
Michele Francesco Di TollaDepartment of Translational Medical Science, University of Naples "Federico II", 80131 Naples, Italy.ORCID 0000-0002-1376-3782
Francesca ZumboloEndocrinology Unit, Department of Clinical Medicine and Surgery, University of Naples "Federico II", Via Sergio Pansini 5, 80131 Naples, Italy.
Pietro FormisanoDepartment of Translational Medical Science, University of Naples "Federico II", 80131 Naples, Italy.ORCID 0000-0001-7020-6870
Filomena MoriscoDiseases of the Liver and Biliary System Unit, Department of Clinical Medicine and Surgery, University of Naples "Federico II", 80131 Naples, Italy.
Silvia SavastanoEndocrinology Unit, Department of Clinical Medicine and Surgery, University of Naples "Federico II", Via Sergio Pansini 5, 80131 Naples, Italy.ORCID 0000-0002-3211-4307
University of Naples Federico II · ITPegaso University · IT

Funding

Ministero dell'istruzione, dell'Università e della Ricerca PRIN2017 E64I19000590001
6 · The paper itself

Abstract

Visceral obesity is linked to the progression of fatty liver to nonalcoholic steatohepatitis (NASH). Cytokeratin-18 (CK18) epitopes M30 (CK18M30) and M65 (CK18M65) represent accurate markers for detecting NASH. The aim of this study was to evaluate the association of CK18M30 and CK18M65 levels with anthropometric and metabolic characteristics, liver stiffness, and liver indices of steatosis and fibrosis in a cohort of subjects with visceral obesity; in this cross-sectional study, transient elastography (TE-Fibroscan

Indexed as

Non-alcoholic Fatty Liver DiseaseBiomarkersCross-Sectional StudiesFibrosisHumansKeratin-18LiverLiver CirrhosisObesity, AbdominalBiomarkersKeratin-18Cytokeratin-18non-alcoholic fatty liver diseasevisceral obesity

Identifiers

PMID37446065
PMCPMC10341576
OpenAlexW4382752516

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.