Evidence map›Paper›PMID 37446062›Full record

ArticleInternational journal of molecular sciences2023

Osteocytes Exposed to Titanium Particles Inhibit Osteoblastic Cell Differentiation via Connexin 43.

Hao Chai, Qun Huang, Zixue Jiao, Shendong Wang, Chunguang Sun, Dechun Geng, Wei Xu

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Hao ChaiDepartment of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China.ORCID 0000-0003-3511-9135
Qun HuangDepartment of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
Zixue JiaoDepartment of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
Shendong WangDepartment of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
Chunguang SunDepartment of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
Dechun GengDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou 215004, China.
Wei XuDepartment of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
Soochow University · CNFirst Affiliated Hospital of Soochow University · CNSecond Affiliated Hospital of Soochow University · CN

Funding

National Natural Science Foundation of China 81874008Soochow Program of Health Talent Training GSWS2019010
6 · The paper itself

Abstract

Periprosthetic osteolysis (PPO) induced by wear particles is the most severe complication of total joint replacement; however, the mechanism behind PPO remains elusive. Previous studies have shown that osteocytes play important roles in wear-particle-induced osteolysis. In this study, we investigated the effects of connexin 43 (Cx43) on the regulation of osteocyte-to-osteoblast differentiation. We established an in vivo murine model of calvarial osteolysis induced by titanium (Ti) particles. The osteolysis characteristic and osteogenesis markers in the

Indexed as

OsteocytesOsteolysisAnimalsbeta CateninCell DifferentiationConnexin 43MiceOsteoblastsTitaniumbeta CateninConnexin 43Titaniumconnexin 43osteocyteperiprosthetic osteolysisβ-catenin

Identifiers

PMID37446062
PMCPMC10342113
OpenAlexW4382790276

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.