Evidence map›Paper›PMID 37446045›Full record

ArticleInternational journal of molecular sciences2023

Antioxidant and Anti-Inflammatory Mechanisms of Cardamonin through Nrf2 Activation and NF-kB Suppression in LPS-Activated BV-2 Microglial Cells.

Kimberly Barber, Patricia Mendonca, Jasmine A Evans, Karam F A Soliman

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Foods (Basel, Switzerland) · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Anti-Neuroinflammatory Effect of Ombuin fromInternational journal of molecular sciences · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Microglia at the blood brain barrier in health and disease.Frontiers in cellular neuroscience · 2024
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kimberly BarberDivision of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Institute of Public Health, Florida A&M University, Tallahassee, FL 32307, USA.
Patricia MendoncaDepartment of Biology, College of Science and Technology, Florida A&M University, Tallahassee, FL 32307, USA.
Jasmine A EvansDivision of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Institute of Public Health, Florida A&M University, Tallahassee, FL 32307, USA.
Karam F A SolimanDivision of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Institute of Public Health, Florida A&M University, Tallahassee, FL 32307, USA.ORCID 0000-0002-0600-1085
Florida Agricultural and Mechanical University · US

Funding

Research Project-3: Effectiveness of an eHealth intervention for uptake of cervical cancer screening in Hispanic womenU54MD007582 · NIMHD · FLORIDA AGRICULTURAL AND MECHANICAL UNIV · PI Seth Y Ablordeppey · 2019 to 2026
$28.1M
NIMHD NIH HHS U54 MD 007582
6 · The paper itself

Abstract

Chronic oxidative stress (OS) and inflammation are implicated in developing and progressing neurodegenerative diseases (NDs). The chronic activation of microglia cells leads to the overproduction of several substances, including nitric oxide and reactive oxygen species, which can induce neurodegeneration. Natural compounds have recently been investigated for their potential to protect cells from OS and to improve many disease-related conditions. Cardamonin (CD) is a bioactive compound in many plants, such as

Indexed as

AntioxidantsNF-kappa BAnti-Inflammatory AgentsCell LineChalconesHumansInflammationKelch-Like ECH-Associated Protein 1LipopolysaccharidesMicrogliaNF-E2-Related Factor 2Nitric OxideAnti-Inflammatory AgentsAntioxidantscardamoninChalconesKelch-Like ECH-Associated Protein 1LipopolysaccharidesNF-E2-Related Factor 2NF-kappa BNitric Oxidecardamoninmicroglianeurodegenerationneuroinflammationoxidative stress

Identifiers

PMID37446045
PMCPMC10341801
OpenAlexW4382774881

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.