Near-Infrared Autofluorescence (NIRAF) in Atherosclerotic Plaque Dissociates from Intraplaque Hemorrhage and Bilirubin.

Weiyu Chen, James Nadel, Sergey Tumanov, Roland Stocker

Open access · goldAbstract read

In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.5field-weighted citation impact, top 34% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

Angiogenesis within atherosclerotic plaques: Mechanical regulation, molecular mechanism and clinical diagnosis.Mechanobiology in medicine · 2025
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Weiyu ChenHeart Research Institute, Sydney, NSW 2042, Australia.

James NadelHeart Research Institute, Sydney, NSW 2042, Australia.

Sergey TumanovHeart Research Institute, Sydney, NSW 2042, Australia.ORCID 0000-0002-0557-3153

Roland StockerHeart Research Institute, Sydney, NSW 2042, Australia.ORCID 0000-0002-7414-6681

The University of Sydney · AUThe Heart Research Institute · AU

Funding

National Health and Medical Research Council 1052616National Health and Medical Research Council 1111632National Health and Medical Research Council PhD ScholarshipNational Heart Foundation of Australia PhD ScholarshipNSW Department of Health Senior Scientist GrantThe China Scholarship Council PhD ScholarshipUNSW Sydney PhD Scholarship

6 · The paper itself

Abstract

Near-infrared autofluorescence (NIRAF) in unstable atherosclerotic plaque has been suggested as a novel imaging technology for high-risk atherosclerosis. Intraplaque hemorrhage (IPH) and bilirubin, derived from the subsequent degradation of heme, have been proposed as the source of NIRAF, although their roles and the underlying mechanism responsible for NIRAF remain unclear. To test the proposed role of bilirubin as the source of NIRAF in high-risk atherosclerosis,

Indexed as

AtherosclerosisPlaque, AtheroscleroticAnimalsApolipoproteins EBilirubinHemorrhageHumansMiceApolipoproteins EBilirubinatherosclerosisbilirubinintraplaque hemorrhage (IPH)near-infrared autofluorescence (NIRAF)

Identifiers

PMID37445903

DOI10.3390/ijms241310727

PMCPMC10341695

OpenAlexW4382584304

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.