ReviewInternational journal of molecular sciences2023
Toxicity Mechanisms of Copper Nanoparticles and Copper Surfaces on Bacterial Cells and Viruses.
Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 148 citations in OpenAlex.
- Clinical translation and landscape of copper nanoparticles.Drug delivery and translational research · 2026Review
- Heavy metal tolerance in rare actinobacteria from Moroccan mining sites: first report of copper, zinc, and cobalt tolerance and zinc-associated antibacterial activity in Lentzea sp.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- Plant-Mediated Production of Antibacterial Nanomaterials Fulfilling a Reactive Oxygen Species Strategy.International journal of molecular sciences · 2026Review
- Chemical Reduction-Derived Nickel Nanoparticles as Multifunctional Antimicrobial and Wound Healing Agents: Mechanistic, Biocompatibility, and Computational Insights.Biological trace element research · 2026Article
- Metal-Substituted Hydroxyapatite Nanoparticles as Antimicrobial and Osteogenic Biomaterials for Hard-Tissue Applications.Materials (Basel, Switzerland) · 2026Review
- Banana Passion Fruit-Mediated Green Synthesis of Copper(I) Iodide Nanoparticles for Concrete Biodeterioration Control: Antimicrobial Activity, Cytotoxicity, and Mechanical Compatibility.Nanomaterials (Basel, Switzerland) · 2026Article
- Synthesis of a Novel Cone-like Tenorite-Antlerite Nanocomposite and Assessment of Its Photocatalytic and Antibacterial Activity.ACS omega · 2026Article
- Article
- Silver-based N-heterocyclic carbene (NHC) complexes as emerging strategies against antimicrobial resistance.Archives of microbiology · 2026Review
- Article
- Assessment of Bovine Herpesvirus Type 1 (BoHV-1) Stability and Infectivity on Copper, Zinc, and Stainless Steel Surfaces.Veterinary sciences · 2026Article
- Mechanistic paradigms of teratogenicity induced by metallic nanoparticles-a mini review.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Review
- Ecofriendly synthesis and characterization of copper chitosan nanoparticles (CuChNPs) and assessing combined effect of nanoparticles and bismerthiozol against bacterial leaf blight of rice.Scientific reports · 2026Article
- Article
- Surface Oxide Film and Antibacterial Activity of Zirconium-Based Bulk Metallic Glasses.Langmuir : the ACS journal of surfaces and colloids · 2026Article
- Box-Behnken optimized copper oxide nanoparticles from Thymus vulgaris potentiate efficacy against multidrug-resistant bacterial pathogens and exhibit anticancer activity.Bioresources and bioprocessing · 2026Article
- Article
- Photocatalytic performance of CuI/Cu2+ -TiO2 for controlling Magnaporthe oryzae infection in rice plants.PloS one · 2026Article
- Neutrophil membrane-coated nanoparticles for targeted therapy.Discover nano · 2025Review
- Nanoparticle Detection in Biology and Medicine: A Review.Biosensors · 2025Review
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Copper is a metal historically used to prevent infections. One of the most relevant challenges in modern society are infectious disease outbreaks, where copper-based technologies can play a significant role. Currently, copper nanoparticles and surfaces are the most common antimicrobial copper-based technologies. Despite the widespread use of copper on nanoparticles and surfaces, the toxicity mechanism(s) explaining their unique antimicrobial properties are not entirely known. In general, toxicity effects described in bacteria and fungi involve the rupture of membranes, accumulation of ions inside the cell, protein inactivation, and DNA damage. A few studies have associated Cu-toxicity with ROS production and genetic material degradation in viruses. Therefore, understanding the mechanisms of the toxicity of copper nanoparticles and surfaces will contribute to developing and implementing efficient antimicrobial technologies to combat old and new infectious agents that can lead to disease outbreaks such as COVID-19. This review summarizes the current knowledge regarding the microbial toxicity of copper nanoparticles and surfaces and the gaps in this knowledge. In addition, we discuss potential applications derived from discovering new elements of copper toxicity, such as using different molecules or modifications to potentiate toxicity or antimicrobial specificity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.