Evidence map›Paper›PMID 37445679›Full record

ArticleInternational journal of molecular sciences2023

HRD Testing of Ovarian Cancer in Routine Practice: What Are We Dealing With?

Tatiana Kekeeva, Yulia Andreeva, Alexander Tanas, Alexey Kalinkin, Svetlana Khokhlova, Tatiana Tikhomirova, Alexandra Tyulyandina, Anatoly Popov, Maria Kuzmenko, Mikhail Volkonsky and 8 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Trial
  3. Article
  4. Observational
  5. Article
  6. Article
  7. Article
  8. Review
  9. Combination ofFrontiers in oncology · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Tatiana KekeevaLaboratory of Epigenetics, Research Centre for Medical Genetics, Moskvorechie St., 1, 115522 Moscow, Russia.
Yulia AndreevaDepartment of Pathology, Russian Medical Academy of Continuing Professional Education, 125993 Moscow, Russia.
Alexander TanasLaboratory of Epigenetics, Research Centre for Medical Genetics, Moskvorechie St., 1, 115522 Moscow, Russia.ORCID 0000-0002-2177-6743
Alexey KalinkinLaboratory of Epigenetics, Research Centre for Medical Genetics, Moskvorechie St., 1, 115522 Moscow, Russia.ORCID 0000-0001-9215-4581
Svetlana KhokhlovaOncological Department of Medical Treatment, National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after V. I. Kulakov, 117997 Moscow, Russia.
Tatiana TikhomirovaN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia, 115478 Moscow, Russia.
Alexandra TyulyandinaN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia, 115478 Moscow, Russia.
Anatoly PopovNational Medical Research Center of Surgery Named after A. Vishnevsky, Department of Antitumor Drug Therapy, 117997 Moscow, Russia.ORCID 0000-0001-6267-8237
Maria KuzmenkoDepartment of Oncology, Radiology and Radiotherapy, Tyumen State Medical University, 625023 Tyumen, Russia.
Mikhail VolkonskyDay Hospital No. 1, Moscow Municipal Oncological Hospital No. 62, 143423 Moscow, Russia.
Natalia ChernorubashkinaDepartment of Surgical Methods of Treatment No. 9, State Budgetary Healthcare Institution Regional Oncological Dispensary, 664035 Irkutsk, Russia.
Valeria SaevetsGynecological Oncology Department, Chelyabinsk Regional Clinical Centre for Oncology and Nuclear Medicine, 454087 Chelyabinsk, Russia.
Vadim DmitrievDepartment of Theoretical Surgery, Belgorod National Research University, 308015 Belgorod, Russia.
Valentina NechushkinaDepartment of Oncology, Diagnostic Radiology and Radiotherapy, Privolzhsky Research Medical University, 603005 Nizhniy Novgorod, Russia.
Olga VedrovaAstrazeneca Pharmaceuticals LLC, 123112 Moscow, Russia.
Sergei AndreevAstrazeneca Pharmaceuticals LLC, 123112 Moscow, Russia.
Sergey KutsevLaboratory of Epigenetics, Research Centre for Medical Genetics, Moskvorechie St., 1, 115522 Moscow, Russia.
Vladimir StrelnikovLaboratory of Epigenetics, Research Centre for Medical Genetics, Moskvorechie St., 1, 115522 Moscow, Russia.ORCID 0000-0001-9283-902X

Funding

Ministry of Science and Higher Education of the Russian Federation state assignment
6 · The paper itself

Abstract

Assessment of homologous recombination deficiency (HRD) status is now essential for ovarian cancer patient management. The aim of our study was to analyze the influence of ethnic variations, tumor purity, and neoadjuvant chemotherapy (CT) on the determination of HRD scores as well as to evaluate feasibility of HRD testing with the Amoy HRD Focus Assay in routine clinical practice. The HRD status, including the

Indexed as

BRCA1 ProteinOvarian NeoplasmsBRCA2 ProteinFemaleHomologous RecombinationHumansMutationRussiaBRCA1 ProteinBRCA2 ProteinBRCA mutationgenomic instability scorehomologous recombination deficiencypathological responsetumor purity

Identifiers

PMID37445679
PMCPMC10342032

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.