ArticleJournal of clinical medicine2023
Predictive Value of the C-Reactive Protein to Albumin Ratio in 30-Day Mortality after Hip Fracture in Elderly Population: A Retrospective Observational Cohort Study.
Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of multidimensional biomarkers of immune, nutritional, inflammatory, and metabolic status with postoperative outcomes in older hip fracture patients: a systematic review and meta-analysis.Frontiers in nutrition · 2026Pooled it
- Predictive Value of the CRP/Albumin Ratio in Mortality Prediction in Hip Fracture Surgery Patients Admitted to Intensive Care.Life (Basel, Switzerland) · 2026Article
- Preoperative Geriatric Nutritional Risk Index (GNRI) and Comorbidity Burden as Mortality Risk Markers After Proximal Femoral Nailing in Older Patients with Pertrochanteric Hip Fractures.Journal of clinical medicine · 2026Article
- Albumin, mNUTRIC and NRS-2002: Predicting Mortality in Elderly ICU Fracture Patients.Healthcare (Basel, Switzerland) · 2026Article
- Balancing risks in febrile hip fracture patients: is surgical delay more dangerous than infection?Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Preoperative RDW-Based composite score for predicting mortality after hip fracture surgery.BMC musculoskeletal disorders · 2026Article
- Period-Specific Determinants of Mortality After Geriatric Hip Fracture: Insights into Inflammation, Comorbidity and Surgical Timing.Geriatric orthopaedic surgery & rehabilitation · 2026Article
- Impact of chronic obstructive pulmonary disease on mortality in elderly patients with hip fracture: A retrospective cohort study.PloS one · 2026Article
- Low prognostic nutritional index is highly associated with periprosthetic joint infection in revision arthroplasty: a 14-year retrospective cohort study.Journal of orthopaedic surgery and research · 2025Article
- C-Reactive Protein to Albumin Ratio and Prognostic Nutrition Index as a Predictor of Periprosthetic Joint Infection and Early Postoperative Wound Complications in Patients Undergoing Primary Total Hip and Knee Arthroplasty.Diagnostics (Basel, Switzerland) · 2025Article
- Article
- Accuracy of the ACS-NSQIP Risk Calculator, Nottingham Hip Fracture Score and CRP/Albumin Ratio in Predicting Adverse Postoperative Outcomes in the Hip Fracture Surgery: A Lithuanian Single-Centre Prospective Study.Geriatric orthopaedic surgery & rehabilitation · 2025Article
- Association of systemic inflammation response index with mortality risk in older patients with hip fracture: a 10-year retrospective cohort study.Frontiers in medicine · 2024Article
- Construction and validation of a predictive model for the risk of prolonged preoperative waiting time in patients with intertrochanteric fractures.Frontiers in medicine · 2024Article
- Correlation between admission hypoalbuminemia and postoperative urinary tract infections in elderly hip fracture patients.Journal of orthopaedic surgery and research · 2023Observational
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundC-reactive protein (CRP) to Albumin ratio (CAR) has been used in multiple clinical settings to predict early mortality. However, there is a lack of evidence on the predictive role of CAR in 30-day mortality after a hip fracture. The purpose of this study was to establish a potential association between CAR and 30-day mortality and to assess if the CAR Receiving Operating Characteristics curve (ROC) can be a reliable predictor of early mortality.
methodsWe retrospectively reviewed the charts of 676 patients (>65 years) treated for hip fracture between 2006 and 2018. All hip fractures were included. Treatment strategies included closed reduction and internal fixation, open reduction and internal fixation, hemiarthroplasty, or total joint arthroplasty. Statistical analysis included T-test, Pearson correlation for CAR and other markers, ROC curves and area under the curve, Youden Model, and Odds Ratio.
resultsThe 30-day mortality rate analysis showed that higher preoperative levels of CAR were associated with higher early mortality. When analyzing the area under the ROC curve (AUROC) for 30-day mortality, the reported value was 0.816. The point of the ROC curve corresponding to 14.72 was considered a cut-off with a specificity of 87% and a sensibility of 40.8%. When analyzing values higher than 14.72, the 30-day mortality rate was 17.9%, whilst, for values lower than 14.72, the 30-day mortality rate was 1.8%.
conclusionsPatients older than 65 years affected by a hip fracture with increased preoperative levels of CAR are associated with higher 30-day mortality. Despite a moderate sensibility, considering the low cost and the predictivity of CAR, it should be considered a standard predictive marker.
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