ReviewJournal of clinical medicine2023
Prognostic Role of Metabolic Exercise Testing in Heart Failure.
Review in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Metabolic-inflammatory burden predicts mortality in heart failure across population and ICU cohorts.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- Body Mass Index-Adjusted Rectus Femoris Muscle Thickness as a Simple Indicator for Exercise Tolerance in Patients With Heart Failure.Circulation reports · 2026Article
- Time-Course of Physiological Adaptations to High-Intensity Interval Training-Based Cardiac Rehabilitation After Myocardial Infarction.Journal of clinical medicine · 2026Article
- Evaluation of Exercise Tolerance in Cancer Patients With Cardiovascular Complications: A Japanese Single-Center Retrospective Study Using Cardiopulmonary Exercise Testing.Circulation reports · 2026Article
- Coronary microvascular dysfunction in HFpEF: pathophysiologic mechanisms, diagnosis, treatments, and the amplifying potential of sepsis.Frontiers in medicine · 2026Review
- Cardiopulmonary Exercise Testing and HFpEF: Diagnostic and Therapeutic Perspectives.Healthcare (Basel, Switzerland) · 2025Review
- Transition to Advanced Heart Failure: From Identification to Improving Prognosis.Journal of cardiovascular development and disease · 2025Review
- Minute Ventilation/Carbon Dioxide Production Slope Could Predict Short- and Long-Term Prognosis of Patients After Acute Decompensated Heart Failure.Life (Basel, Switzerland) · 2024Article
- Age Differences in Cardiopulmonary Exercise Testing Parameters in Heart Failure with Reduced Ejection Fraction.Medicina (Kaunas, Lithuania) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heart failure is a clinical syndrome with significant heterogeneity in presentation and severity. Serial risk-stratification and prognostication can guide management decisions, particularly in advanced heart failure, when progression toward advanced therapies or end-of-life care is warranted. Each currently utilized prognostic marker carries its own set of challenges in acquisition, reproducibility, accuracy, and significance. Left ventricular ejection fraction is foundational for heart failure syndrome classification after clinical diagnosis and remains the primary parameter for inclusion in most clinical trials; however, it does not consistently correlate with symptoms and functional capacity, which are also independently prognostic in this patient population. Utilizing the left ventricular ejection fraction as the sole basis of prognostication provides an incomplete characterization of this condition and is prone to misguide medical decision-making when used in isolation. In this review article, we survey and exposit the important role of metabolic exercise testing across the heart failure spectrum, as a complementary diagnostic and prognostic modality. Metabolic exercise testing, also known as cardiopulmonary exercise testing, provides a comprehensive evaluation of the multisystem (i.e., neurological, respiratory, circulatory, and musculoskeletal) response to exercise performance. These differential responses can help identify the predominant contributors to exercise intolerance and exercise symptoms. Additionally, the aerobic exercise capacity (i.e., oxygen consumption during exercise) is directly correlated with overall life expectancy and prognosis in many disease states. Specifically in heart failure patients, metabolic exercise testing provides an accurate, objective, and reproducible assessment of the overall circulatory sufficiency and circulatory reserve during physical stress, being able to isolate the concurrent chronotropic and stroke volume responses for a reliable depiction of the circulatory flow rate in real time.
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Registered trials
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