ReviewJournal of clinical medicine2023
The Biology of Chronic Pain and Its Implications for Pain Neuroscience Education: State of the Art.
Review in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of Pain Neuroscience Education in Women With Menstrual Pain
Pain Neuroscience Education's Effect on Memory and Pain Drawings: An Exploratory Study
Chronic Pain, Emotions and Professional Football
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pain neuroscience education in patients with chronic musculoskeletal pain: an umbrella review.Frontiers in neuroscience · 2023Pooled it
- Research hotspots and emerging trends of pain neuroscience education in chronic pain management: A bibliometric visualization study.Medicine · 2026Article
- Does Combining the STarT Back Tool With a Polygenic Risk Score for Chronic Low Back Pain Improve Prediction of Work Disability Over 2 Years?European journal of pain (London, England) · 2026Article
- Therapeutic Patient Education in Adults with Chronic Lower Limb Musculoskeletal Pain: A Scoping Review.Healthcare (Basel, Switzerland) · 2026Review
- Pain Beliefs in the Military: A Qualitative Study Exploring the Perspectives of Instructors Within the Canadian Armed Forces on How Pain Is Addressed in Basic Training and the Broader Military Culture.Canadian journal of pain = Revue canadienne de la douleur · 2026Article
- Mobile Health and Gamification of Chronic Pain Management: A Narrative Review.Current pain and headache reports · 2025Review
- Pain Neuroscience Education on Reducing Opioid Dependency in African American and Caucasian Populations: A Narrative Review.Journal of clinical medicine · 2025Review
- Role of Serum Brain-Derived Neurotrophic Factor as a Biomarker of Chronic Pain in Older Adults.European journal of pain (London, England) · 2025Observational
- Perineural Electrical Dry Needling and Neural Mobilization for Chemotherapy-Induced Peripheral Neuropathy: Case Report.Journal of clinical medicine · 2025Article
- Article
- Navigating HOPE (Hypermobile Online Pain managemEnt): Perspectives and Experiences From People With Hypermobile Ehlers-Danlos Syndrome or Hypermobility Spectrum Disorder on a Condition-Specific Online Pain Management Programme.Health expectations : an international journal of public participation in health care and health policy · 2025Article
- Preoperative Home-Based Multimodal Physiotherapy in Patients Scheduled for a Knee Arthroplasty Who Catastrophize About Their Pain: A Randomized Controlled Trial.Journal of clinical medicine · 2025Article
- Pain neuroscience education through cultural lens: insights, challenges and future implications.The Journal of manual & manipulative therapy · 2024Article
- Pain Neuroscience Education for Acute Pain.International journal of sports physical therapy · 2024Article
- Connecting neuroscience research advances with clinical insights: Reflections from an NHS clinician in pain services.Brain and neuroscience advancesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pain is an individualized experience for the person suffering from chronic pain. Significant strides have been made in the last few decades in understanding various biological changes that coincide with chronic pain. This state-of-the-art overview looks at the current evidence related to the biology of chronic pain and the implications these findings have on the delivery of pain neuroscience education (PNE). The paper summarizes the various (epi)genetic, neural, endocrine, and immune factors discovered and explored in the scientific literature concerning chronic pain. Each of these biological factors has various implications for the content and delivery of PNE. We discuss the future directions these biological factors have for the clinical implementation of PNE by linking the importance of behavior change, optimizing the learning environment, and using an individualized multimodal treatment approach with PNE. In addition, future directions for research of PNE based on these biological factors are provided with importance placed on individualized patient-centered care and how PNE can be used with traditional modes of care and growing trends with other care methods. PNE was originally and continues to be rooted in understanding chronic pain biology and how that understanding can improve patient care and outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.