Evidence map›Paper›PMID 37445107›Full record

ReviewMaterials (Basel, Switzerland)2023

Polyphenols: Natural Preservatives with Promising Applications in Food, Cosmetics and Pharma Industries; Problems and Toxicity Associated with Synthetic Preservatives; Impact of Misleading Advertisements; Recent Trends in Preservation and Legislation.

Priyanka Rathee, Renu Sehrawat, Pooja Rathee, Anurag Khatkar, Esra Küpeli Akkol, Sarita Khatkar, Neelam Redhu, Gizem Türkcanoğlu, Eduardo Sobarzo-Sánchez

Open access · goldAbstract readReview
In one paragraph

Review in Materials (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
14.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 74 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Valorization of Hazelnut (Antioxidants (Basel, Switzerland) · 2025
    Article
  17. Review
  18. Review
  19. Article
  20. Excipients in pharmaceuticals: mechanisms of hypersensitivity and the role of global pharmacovigilance.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 4 countries.

Priyanka RatheeFaculty of Pharmaceutical Sciences, Baba Mastnath University, Rohtak 124021, India.ORCID 0009-0003-0315-7417
Renu SehrawatSchool of Medical and Allied Sciences, K.R. Mangalam University, Gurugram 122103, India.
Pooja RatheeDepartment of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak 124001, India.
Anurag KhatkarDepartment of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak 124001, India.
Esra Küpeli AkkolDepartment of Pharmacognosy, Faculty of Pharmacy, Gazi University, Ankara 06330, Turkey.ORCID 0000-0002-5829-7869
Sarita KhatkarVaish Institute of Pharmaceutical Education and Research, Rohtak 124001, India.
Neelam RedhuDepartment of Microbiology, Maharshi Dayanand University, Rohtak 124001, India.
Gizem TürkcanoğluDepartment of Pharmacognosy, Faculty of Pharmacy, Gazi University, Ankara 06330, Turkey.
Eduardo Sobarzo-SánchezInstituto de Investigación y Postgrado, Facultad de Ciencias de la Salud, Universidad Central de Chile, Santiago 8330507, Chile.ORCID 0000-0002-2790-2544
Baba Mastnath University · INGazi University · TRMaharshi Dayanand University · INIndian Institute of Management Rohtak · INKR Mangalam University · INUniversidade de Santiago de Compostela · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The global market of food, cosmetics, and pharmaceutical products requires continuous tracking of harmful ingredients and microbial contamination for the sake of the safety of both products and consumers as these products greatly dominate the consumer's health, directly or indirectly. The existence, survival, and growth of microorganisms in the product may lead to physicochemical degradation or spoilage and may infect the consumer at another end. It has become a challenge for industries to produce a product that is safe, self-stable, and has high nutritional value, as many factors such as physical, chemical, enzymatic, or microbial activities are responsible for causing spoilage to the product within the due course of time. Thus, preservatives are added to retain the virtue of the product to ensure its safety for the consumer. Nowadays, the use of synthetic/artificial preservatives has become common and has not been widely accepted by consumers as they are aware of the fact that exposure to preservatives can lead to adverse effects on health, which is a major area of concern for researchers. Naturally occurring phenolic compounds appear to be extensively used as bio-preservatives to prolong the shelf life of the finished product. Based on the convincing shreds of evidence reported in the literature, it is suggested that phenolic compounds and their derivatives have massive potential to be investigated for the development of new moieties and are proven to be promising drug molecules. The objective of this article is to provide an overview of the significant role of phenolic compounds and their derivatives in the preservation of perishable products from microbial attack due to their exclusive antioxidant and free radical scavenging properties and the problems associated with the use of synthetic preservatives in pharmaceutical products. This article also analyzes the recent trends in preservation along with technical norms that regulate the food, cosmetic, and pharmaceutical products in the developing countries.

Indexed as

antioxidantmicrobial activitiesnatural phenolic compoundspreservativesradical scavenging

Identifiers

PMID37445107
PMCPMC10343617
OpenAlexW4383104980

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.