Evidence map›Paper›PMID 37444571›Full record

ArticleCancers2023

Alterations in the Epigenetic Machinery Associated with Prostate Cancer Health Disparities.

Jenna Craddock, Jue Jiang, Sean M Patrick, Shingai B A Mutambirwa, Phillip D Stricker, M S Riana Bornman, Weerachai Jaratlerdsiri, Vanessa M Hayes

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Jenna CraddockSchool of Health Systems and Public Health, Faculty of Health Sciences, University of Pretoria, Pretoria 0084, South Africa.ORCID 0000-0003-2373-7227
Jue JiangAncestry and Health Genomics Laboratory, Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW 2006, Australia.
Sean M PatrickSchool of Health Systems and Public Health, Faculty of Health Sciences, University of Pretoria, Pretoria 0084, South Africa.ORCID 0000-0002-0364-0068
Shingai B A MutambirwaDepartment of Urology, Sefako Makgatho Health Science University, Dr George Mukhari Academic Hospital, Medunsa 0208, South Africa.
Phillip D StrickerDepartment of Urology, St Vincent's Hospital, Darlinghurst, NSW 2010, Australia.
M S Riana BornmanSchool of Health Systems and Public Health, Faculty of Health Sciences, University of Pretoria, Pretoria 0084, South Africa.ORCID 0000-0003-3975-2333
Weerachai JaratlerdsiriAncestry and Health Genomics Laboratory, Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW 2006, Australia.ORCID 0000-0001-9100-1807
Vanessa M HayesSchool of Health Systems and Public Health, Faculty of Health Sciences, University of Pretoria, Pretoria 0084, South Africa.ORCID 0000-0002-4524-7280
The University of Sydney · AUUniversity of Pretoria · ZASefako Makgatho Health Sciences University · ZASt Vincent's Hospital Sydney · AU

Funding

Cancer Association of South Africa BornmanCongressionally Directed Medical Research Programs PC200390; PC210168National Health and Medical Research Council APP2001098National Research Foundation PMDS22070633683Petre Foundation, Australia Petre Chair
6 · The paper itself

Abstract

Prostate cancer is driven by acquired genetic alterations, including those impacting the epigenetic machinery. With African ancestry as a significant risk factor for aggressive disease, we hypothesize that dysregulation among the roughly 656 epigenetic genes may contribute to prostate cancer health disparities. Investigating prostate tumor genomic data from 109 men of southern African and 56 men of European Australian ancestry, we found that African-derived tumors present with a longer tail of epigenetic driver gene candidates (72 versus 10). Biased towards African-specific drivers (63 versus 9 shared), many are novel to prostate cancer (18/63), including several putative therapeutic targets (

Indexed as

African ancestryepigenetic machineryepigenomicshealth disparityprostate cancersomatic alterationsouthern Africa

Identifiers

PMID37444571
PMCPMC10341375
OpenAlexW4382941165

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.