Evidence map›Paper›PMID 37444561›Full record

ArticleCancers2023

Co-Targeting FASN and mTOR Suppresses Uveal Melanoma Growth.

Anna Han, Dzmitry Mukha, Vivian Chua, Timothy J Purwin, Manoela Tiago, Bhavik Modasia, Usman Baqai, Jenna L Aumiller, Nelisa Bechtel, Emily Hunter and 10 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Gene therapy for uveal melanoma.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  3. Article
  4. The Roles of PTEN in Melanoma Suppression.Pigment cell & melanoma research · 2025
    Review
  5. Metabolic Inhibition Induces Pyroptosis in Uveal Melanoma.Molecular cancer research : MCR · 2025
    Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 3 countries.

Anna HanDepartment of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.ORCID 0000-0001-8180-6214
Dzmitry MukhaMolecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA 19104, USA.ORCID 0000-0003-3027-6270
Vivian ChuaDepartment of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.ORCID 0000-0002-1873-6820
Timothy J PurwinDepartment of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Manoela TiagoDepartment of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.ORCID 0000-0003-0536-2580
Bhavik ModasiaDepartment of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Usman BaqaiDepartment of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Jenna L AumillerDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Nelisa BechtelDepartment of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Emily HunterDepartment of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Meggie DanielsonDepartment of Medical Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Mizue TeraiDepartment of Medical Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Philip B WedegaertnerDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.ORCID 0000-0001-9264-4759
Takami SatoDepartment of Medical Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA.ORCID 0000-0003-2221-0415
Solange LandrevilleDepartment of Ophthalmology and Otorhinolaryngology-Cervical-Facial Surgery, Faculty of Medicine, Université Laval, Québec, QC G1V 0A6, Canada.ORCID 0000-0002-9164-0657
Michael A DaviesDepartment of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0002-0977-0912
Stefan KurtenbachBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33101, USA.
J William HarbourBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33101, USA.ORCID 0000-0002-1104-9809
Zachary T SchugMolecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA 19104, USA.
Andrew E AplinDepartment of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Thomas Jefferson University · USThe Wistar Institute · USUniversity of Miami · USThe University of Texas MD Anderson Cancer Center · USUniversité Laval · CA

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DIANE BODURKA · 1985 to 2026
$290.8M
Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Aaron Robert Goldman · 1985 to 2026
$75.9M
Targeting the MAP and PI3 Kinase Pathways in MelanomaP01CA114046 · NCI · WISTAR INSTITUTE · PI XU, XIAOWEI · 2008 to 2023
$37.1M
The multifaceted role of acetate in cancerDP2CA249950 · NCI · WISTAR INSTITUTE · PI SCHUG, ZACHARY T · 2019 to 2019
$2.7M
Targeting Systems Vulnerabilities in the Gαq/GNAQ Oncogenic Signaling Circuitry: New Precision Therapies for Uveal MelanomaR01CA257505 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI APLIN, ANDREW ERIC, GUTKIND, JORGE SILVIO · 2021 to 2025
$2.7M
Mechanisms of uveal melanoma dormancy and targeted therapy toleranceR01CA253977 · NCI · THOMAS JEFFERSON UNIVERSITY · PI AGUIRRE-GHISO, JULIO A., APLIN, ANDREW ERIC · 2020 to 2024
$2.4M
Training Grant in Cellular, Biochemical and Molecular SciencesT32GM144302 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI DIANE E MERRY, PHILIP B WEDEGAERTNER · 2022 to 2026
$2.0M
Mutant BRAF-regulated transcription factors in melanoma progressionR01CA196278 · NCI · THOMAS JEFFERSON UNIVERSITY · PI APLIN, ANDREW ERIC · 2015 to 2019
$1.8M
Regulation of Mutationally Activated Gq/11R01GM138943 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI WEDEGAERTNER, PHILIP B · 2021 to 2024
$1.2M
Functional Proteomics by Reverse Phase Protein Array in CancerR50CA221675 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LU, YILING · 2017 to 2021
$726k
Melanoma Research Alliance 559058NCI NIH HHS DP2 CA249950NCI NIH HHS NCI CA16672NCI NIH HHS P01 CA114046NCI NIH HHS P30 CA010815NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA196278NCI NIH HHS R01 CA253977NCI NIH HHS R01 CA257505NCI NIH HHS R50 CA221675NIGMS NIH HHS R01 GM138943NIGMS NIH HHS T32 GM144302NIH HHS NIH R50CA221675NIH HHS P01 CA114046NIH HHS R01 CA196278NIH HHS R01 CA253977NIH HHS R01 CA257505
6 · The paper itself

Abstract

Uveal melanoma (UM) displays a high frequency of metastasis; however, effective therapies for metastatic UM are limited. Identifying unique metabolic features of UM may provide a potential targeting strategy. A lipid metabolism protein expression signature was induced in a normal choroidal melanocyte (NCM) line transduced with

Indexed as

fatty acid synthaseGNAQmetabolic inhibitionmTOR pathwayuveal melanoma

Identifiers

PMID37444561
PMCPMC10341317
OpenAlexW4382941063

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.