Evidence map›Paper›PMID 37444560›Full record

ArticleCancers2023

Analysis of the Peritumoral Tissue Unveils Cellular Changes Associated with a High Risk of Recurrence.

Audrey Michot, Pauline Lagarde, Tom Lesluyes, Elodie Darbo, Agnès Neuville, Jessica Baud, Gaëlle Perot, Iris Bonomo, Mathilde Maire, Maxime Michot and 3 more

Abstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Audrey MichotBordeaux Institute of Oncology, BRIC U1312, INSERM, 33000 Bordeaux, France.
Pauline LagardeInstitut Bergonié, Centre de Lutte Contre le Cancer de Bordeaux, 33076 Bordeaux, France.
Tom LesluyesInstitut Bergonié, Centre de Lutte Contre le Cancer de Bordeaux, 33076 Bordeaux, France.
Elodie DarboBordeaux Institute of Oncology, BRIC U1312, INSERM, 33000 Bordeaux, France.ORCID 0000-0002-6692-4949
Agnès NeuvilleInstitut Bergonié, Centre de Lutte Contre le Cancer de Bordeaux, 33076 Bordeaux, France.
Jessica BaudBordeaux Institute of Oncology, BRIC U1312, INSERM, 33000 Bordeaux, France.
Gaëlle PerotOncoSarc, INSERM U1037, Cancer Research Center in Toulouse (CRCT), 31000 Toulouse, France.
Iris BonomoInstitut Bergonié, Centre de Lutte Contre le Cancer de Bordeaux, 33076 Bordeaux, France.
Mathilde MaireInstitut Bergonié, Centre de Lutte Contre le Cancer de Bordeaux, 33076 Bordeaux, France.
Maxime MichotInstitut Bergonié, Centre de Lutte Contre le Cancer de Bordeaux, 33076 Bordeaux, France.
Jean-Michel CoindreInstitut Bergonié, Centre de Lutte Contre le Cancer de Bordeaux, 33076 Bordeaux, France.
François Le LoarerBordeaux Institute of Oncology, BRIC U1312, INSERM, 33000 Bordeaux, France.
Frédéric ChibonOncoSarc, INSERM U1037, Cancer Research Center in Toulouse (CRCT), 31000 Toulouse, France.ORCID 0000-0002-6548-2181

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe management of soft-tissue sarcoma (STS) relies on a multidisciplinary approach involving specialized oncological surgery combined with other adjuvant therapies to achieve optimal local disease control. Purpose and Results: Genomic and transcriptomic pseudocapsules of 20 prospective sarcomas were analyzed and revealed to be correlated with a higher risk of recurrence after surgery.

conclusionsA peritumoral environment that has been remodeled and infiltrated by M2 macrophages, and is less expressive of healthy tissue, would pose a significant risk of relapse and require more aggressive treatment strategies.

Indexed as

molecular changesperitumoral capsuleperitumoral tissuerecurrencesoft-tissue sarcoma

Identifiers

PMID37444560
PMCPMC10340275

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.