Evidence map›Paper›PMID 37444530›Full record

ArticleCancers2023

Overview of the Genetic Causes of Hereditary Breast and Ovarian Cancer Syndrome in a Large French Patient Cohort.

Ahmed Bouras, Souhir Guidara, Mélanie Leone, Adrien Buisson, Tanguy Martin-Denavit, Sophie Dussart, Christine Lasset, Sophie Giraud, Marie-Noëlle Bonnet-Dupeyron, Zine-Eddine Kherraf and 6 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
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  6. The Molecular Detection of Germline Mutations in theCurrent issues in molecular biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 2 countries.

Ahmed BourasLaboratory of Constitutional Genetics for Frequent Cancer HCL-CLB, Centre Léon Bérard, 69008 Lyon, France.ORCID 0000-0003-0243-8295
Souhir GuidaraDepartment of Genetics, Groupement Hospitalier EST, Hospices Civils de Lyon, 69500 Bron, France.
Mélanie LeoneDepartment of Genetics, Groupement Hospitalier EST, Hospices Civils de Lyon, 69500 Bron, France.
Adrien BuissonDepartment of Biopathology, Centre Léon Bérard, 69008 Lyon, France.
Tanguy Martin-DenavitDepartment of Genetics, Groupement Hospitalier EST, Hospices Civils de Lyon, 69500 Bron, France.
Sophie DussartCentre Léon Bérard, Unité de Prévention et Epidémiologie Génétique, 69008 Lyon, France.
Christine LassetCentre Léon Bérard, Unité de Prévention et Epidémiologie Génétique, 69008 Lyon, France.
Sophie GiraudDepartment of Genetics, Groupement Hospitalier EST, Hospices Civils de Lyon, 69500 Bron, France.
Marie-Noëlle Bonnet-DupeyronDepartment of Genetics, Valence Hospital's Center, 26362 Valence, France.
Zine-Eddine KherrafInstitute for Advanced Biosciences, University Grenoble Alpes, INSERM, CNRS, 38000 Grenoble, France.ORCID 0000-0003-0351-6689
Damien SanlavilleDepartment of Genetics, Groupement Hospitalier EST, Hospices Civils de Lyon, 69500 Bron, France.
Sandra Fert-FerrerGenetics Departement, Centre Hospitalier Métropole Savoie, 73011 Chambery, France.
Marine LebrunDepartment of Genetics, Saint Etienne University Hospital, 42270 Saint Priez en Jarez, France.
Valerie BonadonaCentre Léon Bérard, Unité de Prévention et Epidémiologie Génétique, 69008 Lyon, France.
Alain CalenderDepartment of Genetics, Groupement Hospitalier EST, Hospices Civils de Lyon, 69500 Bron, France.
Nadia Boutry-KryzaDepartment of Genetics, Groupement Hospitalier EST, Hospices Civils de Lyon, 69500 Bron, France.
Hospices Civils de Lyon · FRCentre Léon Bérard · FRCentre National de la Recherche Scientifique · FRCentre Hospitalier de Valence · FRCentre Hospitalier Métropole Savoie · FRInstitute Cancer De La Loire Lucien Neuwirth · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of multigene panel testing for patients with a predisposition to Hereditary Breast and Ovarian Cancer syndrome (HBOC) is increasing as the identification of mutations is useful for diagnosis and disease management. Here, we conducted a retrospective analysis of BRCA1/2 and non-BRCA gene sequencing in 4630 French HBOC suspected patients. Patients were investigated using a germline cancer panel including the 13 genes defined by The French Genetic and Cancer Group (GGC)-Unicancer. In the patients analyzed, 528 pathogenic and likely pathogenic variants (P/LP) were identified, including

Indexed as

BRCA geneHBOCmultigene panelNGSRNA analysis

Identifiers

PMID37444530
PMCPMC10341368
OpenAlexW4382775116

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.