Evidence map›Paper›PMID 37444528›Full record

ArticleCancers2023

Late Effects of Chronic Low Dose Rate Total Body Irradiation on the Heart Proteome of ApoE

Omid Azimzadeh, Juliane Merl-Pham, Vikram Subramanian, Kateryna Oleksenko, Franziska Krumm, Mariateresa Mancuso, Emanuela Pasquali, Ignacia B Tanaka, Satoshi Tanaka, Michael J Atkinson and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 4 countries.

Omid AzimzadehSection of Radiation Biology, Federal Office of Radiation Protection (BfS), 85764 Nauenberg, Germany.ORCID 0000-0001-8984-0388
Juliane Merl-PhamMetabolomics and Proteomics Core, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, 85764 Munich, Germany.ORCID 0000-0002-3422-4083
Vikram SubramanianAbboud Cardiovascular Research Center, Division of Cardiovascular Medicine, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Kateryna OleksenkoInstitute of Radiation Biology, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, 85764 Neuherberg, Germany.
Franziska KrummSection of Radiation Biology, Federal Office of Radiation Protection (BfS), 85764 Nauenberg, Germany.
Mariateresa MancusoLaboratory of Biomedical Technologies, Agenzia Nazionale per le Nuove Tecnologie, l'Energia e lo Sviluppo Economico Sostenibile (ENEA), 00196 Rome, Italy.ORCID 0000-0002-0912-9287
Emanuela PasqualiLaboratory of Biomedical Technologies, Agenzia Nazionale per le Nuove Tecnologie, l'Energia e lo Sviluppo Economico Sostenibile (ENEA), 00196 Rome, Italy.ORCID 0000-0002-3997-0659
Ignacia B TanakaInstitute for Environmental Sciences (IES), Rokkasho, Aomori 039-3212, Japan.ORCID 0000-0002-9526-0184
Satoshi TanakaInstitute for Environmental Sciences (IES), Rokkasho, Aomori 039-3212, Japan.
Michael J AtkinsonInstitute of Radiation Biology, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, 85764 Neuherberg, Germany.
Soile TapioInstitute of Radiation Biology, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, 85764 Neuherberg, Germany.
Simone MoertlSection of Radiation Biology, Federal Office of Radiation Protection (BfS), 85764 Nauenberg, Germany.
Federal Office for Radiation Protection · DEHelmholtz Zentrum München · DEInstitute for Environmental Sciences · JPNational Agency for New Technologies, Energy and Sustainable Economic Development · ITTUM Klinikum · DEUniversity of Iowa · US

Funding

European Community's Seventh Framework Program (EURATOM), PROCARDIO 295823
6 · The paper itself

Abstract

Recent epidemiologic studies support an association between chronic low-dose radiation exposure and the development of cardiovascular disease (CVD). The molecular mechanisms underlying the adverse effect of chronic low dose exposure are not fully understood. To address this issue, we have investigated changes in the heart proteome of ApoE deficient (ApoE

Indexed as

ageingAMPKcardiovascular diseasechronic exposureheartionising radiationoxidative stressPPARαproteomicsSIRTTBITGFβ

Identifiers

PMID37444528
PMCPMC10340334
OpenAlexW4382776407

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.