Evidence map›Paper›PMID 37444472›Full record

ArticleCancers2023

Identification of Tissue-Resident Natural Killer and T Lymphocytes with Anti-Tumor Properties in Ascites of Ovarian Cancer Patients.

Elin Bernson, Oisín Huhn, Veronika Karlsson, Delia Hawkes, Maria Lycke, Valentina Cazzetta, Joanna Mikulak, James Hall, Anna M Piskorz, Rosalba Portuesi and 9 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  7. Origin of Hypofunctional CD103European journal of immunology · 2025
    Article
  8. Article
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  10. Review
  11. Article
  12. Article
  13. Transcriptional signature of CD56Frontiers in immunology · 2024
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 5 countries.

Elin BernsonDepartment of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine, NIHR Cambridge Biomedical Research Centre, Addenbrooke's Hosptial, Cambridge CB2 0QQ, UK.ORCID 0000-0001-6414-5725
Oisín HuhnDepartment of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine, NIHR Cambridge Biomedical Research Centre, Addenbrooke's Hosptial, Cambridge CB2 0QQ, UK.
Veronika KarlssonSahlgrenska Center for Cancer Research, Department of Obstetrics and Gynecology, Institute of Clinical Sciences, University of Gothenburg, 405 30 Gothenburg, Sweden.
Delia HawkesDepartment of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine, NIHR Cambridge Biomedical Research Centre, Addenbrooke's Hosptial, Cambridge CB2 0QQ, UK.
Maria LyckeSahlgrenska Center for Cancer Research, Department of Obstetrics and Gynecology, Institute of Clinical Sciences, University of Gothenburg, 405 30 Gothenburg, Sweden.
Valentina CazzettaLaboratory of Clinical and Experimental Immunology, IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, Italy.ORCID 0000-0001-7183-2793
Joanna MikulakLaboratory of Clinical and Experimental Immunology, IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, Italy.
James HallCancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 1TN, UK.
Anna M PiskorzCancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 1TN, UK.
Rosalba PortuesiUnit of Gynecology, IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, Italy.
Domenico VitobelloUnit of Gynecology, IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, Italy.
Barbara FiamengoUnit of Pathological Anatomy, IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, Italy.
Gabriele SiestoUnit of Gynecology, IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, Italy.ORCID 0000-0003-1316-2589
Amir HorowitzDepartment of Oncological Sciences, Lipschultz Precision Immunology Institute, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Hormas GhadiallyAstraZeneca, Oncology R&D, Granta Park, Cambridge CB21 6GP, UK.
Domenico MavilioLaboratory of Clinical and Experimental Immunology, IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, Italy.ORCID 0000-0001-6147-0952
James D BrentonCancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 1TN, UK.
Karin SundfeldtSahlgrenska Center for Cancer Research, Department of Obstetrics and Gynecology, Institute of Clinical Sciences, University of Gothenburg, 405 30 Gothenburg, Sweden.ORCID 0000-0002-7135-3132
Francesco ColucciDepartment of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine, NIHR Cambridge Biomedical Research Centre, Addenbrooke's Hosptial, Cambridge CB2 0QQ, UK.ORCID 0000-0001-5193-6376
University of Cambridge · GBIRCCS Humanitas Research Hospital · ITUniversity of Gothenburg · SEUniversity of Milan · ITAstraZeneca (United Kingdom) · GBTisch Hospital · US

Funding

Cancer Research UK 15601Cancer Research UK 22905Wellcome Trust 094073/Z/10/Z
6 · The paper itself

Abstract

Women with ovarian cancer have limited therapy options, with immunotherapy being unsatisfactory for a large group of patients. Tumor cells spread from the ovary or the fallopian tube into the abdominal cavity, which is commonly accompanied with massive ascites production. The ascites represents a unique peritoneal liquid tumor microenvironment with the presence of both tumor and immune cells, including cytotoxic lymphocytes. We characterized lymphocytes in ascites from patients with high-grade serous ovarian cancer. Our data reveal the presence of NK and CD8

Indexed as

NK cellsNKG2Aovarian cancertissue-resident lymphocytes

Identifiers

PMID37444472
PMCPMC10340516
OpenAlexW4382459156

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.