Evidence map›Paper›PMID 37444471›Full record

ArticleCancers2023

Frequency and Predictors of Dysplasia in Pseudopolyp-like Colorectal Lesions in Patients with Long-Standing Inflammatory Bowel Disease.

Elena De Cristofaro, Elisabetta Lolli, Stefano Migliozzi, Stella Sincovih, Irene Marafini, Francesca Zorzi, Edoardo Troncone, Benedetto Neri, Livia Biancone, Giovanna Del Vecchio Blanco and 2 more

Abstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Elena De CristofaroAzienda Ospedaliera Policlinico Tor Vergata, 00133 Rome, Italy.
Elisabetta LolliAzienda Ospedaliera Policlinico Tor Vergata, 00133 Rome, Italy.
Stefano MigliozziDepartment of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Stella SincovihDepartment of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Irene MarafiniAzienda Ospedaliera Policlinico Tor Vergata, 00133 Rome, Italy.
Francesca ZorziAzienda Ospedaliera Policlinico Tor Vergata, 00133 Rome, Italy.
Edoardo TronconeAzienda Ospedaliera Policlinico Tor Vergata, 00133 Rome, Italy.
Benedetto NeriDepartment of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Livia BianconeAzienda Ospedaliera Policlinico Tor Vergata, 00133 Rome, Italy.ORCID 0000-0002-9056-1957
Giovanna Del Vecchio BlancoAzienda Ospedaliera Policlinico Tor Vergata, 00133 Rome, Italy.ORCID 0000-0002-6327-563X
Emma CalabreseAzienda Ospedaliera Policlinico Tor Vergata, 00133 Rome, Italy.
Giovanni MonteleoneAzienda Ospedaliera Policlinico Tor Vergata, 00133 Rome, Italy.ORCID 0000-0003-1339-9076

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current endoscopic surveillance programs do not consider inflammatory bowel disease (IBD)-associated post-inflammatory polyps (pseudopolyps) per se clinically relevant, even though their presence seems to increase the risk of colorectal cancer (CRC). However, it remains unclear whether the link between pseudopolyps and CRC is indirect or whether some subsets of pseudopolyp-like lesions might eventually undergo neoplastic transformation. This study aimed to assess the frequency and predictors of dysplasia in pseudopolyp-like lesions in a population with long-standing colonic IBD. This was a retrospective, single-center study including patients with a colonic IBD (median disease duration of 192 months) and at least a pseudopolyp-like lesion biopsied or resected in the period from April 2021 to November 2022. One hundred and five pseudopolyps were identified in 105 patients (80 with ulcerative colitis and 25 with Crohn's disease). Twenty-three out of 105 pseudopolyp samples (22%) had dysplastic foci, and half of the dysplastic lesions were hyperplastic. Multivariate analysis showed that the age of the patients (odds ratio (OR) 1.1;

Indexed as

colitis-associated colorectal cancerCrohn’s diseasesurveillance colonoscopyulcerative colitis

Identifiers

PMID37444471
PMCPMC10341039

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.