Evidence map›Paper›PMID 37444408›Full record

ReviewCancers2023

Insights into the Role of LncRNAs and miRNAs in Glioma Progression and Their Potential as Novel Therapeutic Targets.

Mateusz Kciuk, Esam Bashir Yahya, Montaha Mohamed Ibrahim Mohamed, Muhanad A Abdulsamad, Abdulmutalib A Allaq, Adrianna Gielecińska, Renata Kontek

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Mateusz KciukDepartment of Molecular Biotechnology and Genetics, University of Lodz, 90-237 Lodz, Poland.ORCID 0000-0002-8616-3825
Esam Bashir YahyaBioprocess Technology Division, School of Industrial Technology, Universiti Sains Malaysia, Penang 11800, Malaysia.ORCID 0000-0002-1599-1754
Montaha Mohamed Ibrahim MohamedFaculty of Applied Medical Sciences, Mohail Aseer, King Khalid University, Abha 62529, Saudi Arabia.
Muhanad A AbdulsamadDepartment of Molecular Biology, Faculty of Science, Sabratha University, Sabratha 00218, Libya.
Abdulmutalib A AllaqFaculty of Applied Science, Universiti Teknologi MARA, Shah Alam 40450, Malaysia.
Adrianna GielecińskaDepartment of Molecular Biotechnology and Genetics, University of Lodz, 90-237 Lodz, Poland.ORCID 0000-0001-9562-3582
Renata KontekDepartment of Molecular Biotechnology and Genetics, University of Lodz, 90-237 Lodz, Poland.ORCID 0000-0003-2859-9839
University of Łódź · PLKing Khalid University · SAUniversiti Sains Malaysia · MYUniversiti Teknologi MARA · MY

Funding

King Khalid University through large group Research Project RGP2/388/44the University of Lodz order no. 18 of the Rector of the University of Lodz of October 23, 2019
6 · The paper itself

Abstract

Accumulating evidence supports that both long non-coding and micro RNAs (lncRNAs and miRNAs) are implicated in glioma tumorigenesis and progression. Poor outcome of gliomas has been linked to late-stage diagnosis and mostly ineffectiveness of conventional treatment due to low knowledge about the early stage of gliomas, which are not possible to observe with conventional diagnostic approaches. The past few years witnessed a revolutionary advance in biotechnology and neuroscience with the understanding of tumor-related molecules, including non-coding RNAs that are involved in the angiogenesis and progression of glioma cells and thus are used as prognostic biomarkers as well as novel therapeutic targets. The emerging research on lncRNAs and miRNAs highlights their crucial role in glioma progression, offering new insights into the disease. These non-coding RNAs hold significant potential as novel therapeutic targets, paving the way for innovative treatment approaches against glioma. This review encompasses a comprehensive discussion about the role of lncRNAs and miRNAs in gene regulation that is responsible for the promotion or the inhibition of glioma progression and collects the existing links between these key cancer-related molecules.

Indexed as

brain tumorsgene therapygliomalong RMAmicro non-coding RNAs

Identifiers

PMID37444408
PMCPMC10340789
OpenAlexW4381741971

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.