Evidence map›Paper›PMID 37444378›Full record

ArticleCancers2023

Assessing the Performance of a Novel Stool-Based Microbiome Test That Predicts Response to First Line Immune Checkpoint Inhibitors in Multiple Cancer Types.

Irina Robinson, Maximilian Johannes Hochmair, Manuela Schmidinger, Gudrun Absenger, Martin Pichler, Van Anh Nguyen, Erika Richtig, Barbara Margaretha Rainer, Leyla Ay, Christian Jansen and 5 more

Abstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Irina RobinsonDepartment of Respiratory and Critical Care Medicine, Karl Landsteiner Institute for Lung Research and Pulmonary Oncology, Klinik Floridsdorf, Vienna Healthcare Group, 1210 Vienna, Austria.
Maximilian Johannes HochmairDepartment of Respiratory and Critical Care Medicine, Karl Landsteiner Institute for Lung Research and Pulmonary Oncology, Klinik Floridsdorf, Vienna Healthcare Group, 1210 Vienna, Austria.ORCID 0000-0002-8673-2450
Manuela SchmidingerDepartment of Urology, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.
Gudrun AbsengerDepartment of Internal Medicine, Division of Oncology, Medical University of Graz, 8036 Graz, Austria.
Martin PichlerDepartment of Internal Medicine, Division of Oncology, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0002-8701-9462
Van Anh NguyenDepartment of Dermatology, Medical University Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0003-2087-447X
Erika RichtigDepartment of Dermatology, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0002-5505-6103
Barbara Margaretha RainerDepartment of Dermatology, Medical University of Graz, 8036 Graz, Austria.
Leyla AyDepartment of Respiratory and Critical Care Medicine, Karl Landsteiner Institute for Lung Research and Pulmonary Oncology, Klinik Floridsdorf, Vienna Healthcare Group, 1210 Vienna, Austria.
Christian JansenBiome Diagnostics GmbH, 1200 Vienna, Austria.
Cátia PacíficoBiome Diagnostics GmbH, 1200 Vienna, Austria.ORCID 0000-0002-6278-5777
Alexander KnablBiome Diagnostics GmbH, 1200 Vienna, Austria.
Barbara SladekBiome Diagnostics GmbH, 1200 Vienna, Austria.
Nikolaus GascheBiome Diagnostics GmbH, 1200 Vienna, Austria.ORCID 0000-0002-2811-1656
Arschang ValipourDepartment of Respiratory and Critical Care Medicine, Karl Landsteiner Institute for Lung Research and Pulmonary Oncology, Klinik Floridsdorf, Vienna Healthcare Group, 1210 Vienna, Austria.

Funding

Biome Diagnostics GmbH Biome Diagnostics GmbH
6 · The paper itself

Abstract

The intestinal microbiome is by now an undebatable key player in the clinical outcome of ICI therapies. However, no microbiome profiling method to aid therapy decision is yet validated. We conducted a multi-centric study in patients with stage III/IV melanoma, NSCLC, or RCC receiving ICI treatment. The stool microbiome profile of 63 patients was analyzed with BiomeOne

Indexed as

gut microbiomeimmunotherapymicrobiome profilingnext generation sequencingPD-L1

Identifiers

PMID37444378
PMCPMC10339964

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.