Evidence map›Paper›PMID 37443829›Full record

ArticleCells2023

A YAP/TAZ-ARHGAP29-RhoA Signaling Axis Regulates Podocyte Protrusions and Integrin Adhesions.

Manuel Rogg, Jasmin I Maier, Martin Helmstädter, Alena Sammarco, Felix Kliewe, Oliver Kretz, Lisa Weißer, Clara Van Wymersch, Karla Findeisen, Anna L Koessinger and 8 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. ARHGAP29 promotes keratinocyte proliferation and migration in vitro and is dispensable for in vivo wound healing.Developmental dynamics : an official publication of the American Association of Anatomists · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 2 countries.

Manuel RoggInstitute of Surgical Pathology, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.ORCID 0000-0002-6658-9159
Jasmin I MaierInstitute of Surgical Pathology, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.ORCID 0000-0003-4158-2935
Martin HelmstädterDepartment of Medicine IV, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.ORCID 0000-0001-6027-0094
Alena SammarcoInstitute of Surgical Pathology, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Felix KlieweDepartment of Anatomy and Cell Biology, University Medicine Greifswald, 17489 Greifswald, Germany.
Oliver KretzIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Lisa WeißerInstitute of Surgical Pathology, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Clara Van WymerschInstitute of Surgical Pathology, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Karla FindeisenInstitute of Surgical Pathology, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Anna L KoessingerInstitute of Surgical Pathology, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Olga TsoyInstitute for Computational Systems Biology, University of Hamburg, 22607 Hamburg, Germany.
Jan BaumbachInstitute for Computational Systems Biology, University of Hamburg, 22607 Hamburg, Germany.
Markus GrabbertDepartment of Urology, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Martin WernerInstitute of Surgical Pathology, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Tobias B HuberIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Nicole EndlichDepartment of Anatomy and Cell Biology, University Medicine Greifswald, 17489 Greifswald, Germany.
Oliver SchillingInstitute of Surgical Pathology, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Christoph SchellInstitute of Surgical Pathology, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
University of Freiburg · DEUniversität Hamburg · DEUniversitätsmedizin Greifswald · DE

Funding

Deutsche Forschungsgemeinschaft 241702976Deutsche Forschungsgemeinschaft 256073931Deutsche Forschungsgemeinschaft 386793560Deutsche Forschungsgemeinschaft 431984000Deutsche Forschungsgemeinschaft 438496892Deutsche Forschungsgemeinschaft CRC1192, HU 1016/8-2, HU 1016/11-1, HU 1016/ 12-1Deutsche Forschungsgemeinschaft KR 1984/4-1Federal Ministry of Education and Research STOP-FSGS-01GM2202A
6 · The paper itself

Abstract

Glomerular disease due to podocyte malfunction is a major factor in the pathogenesis of chronic kidney disease. Identification of podocyte-specific signaling pathways is therefore a prerequisite to characterizing relevant disease pathways and developing novel treatment approaches. Here, we employed loss of function studies for

Indexed as

PodocytesAdaptor Proteins, Signal TransducingGTPase-Activating ProteinsHumansIntegrinsMechanotransduction, CellularMembrane ProteinsProteomicsrhoA GTP-Binding ProteinSignal TransductionYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingARHGAP29 protein, humanEPB41L5 protein, humanGTPase-Activating ProteinsIntegrinsMembrane ProteinsrhoA GTP-Binding ProteinYAP-Signaling ProteinsARHGAP29EPB41L5glomerular kidney diseasemechanotransductionpodocyteYAP/TAZYurt

Identifiers

PMID37443829
PMCPMC10340513
OpenAlexW4383536324

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.