Evidence map›Paper›PMID 37443796›Full record

ArticleCells2023

Adenovirus-Based Gene Therapy for Bone Regeneration: A Comparative Analysis of In Vivo and Ex Vivo

Tatiana Borisovna Bukharova, Irina Alekseevna Nedorubova, Viktoria Olegovna Mokrousova, Anastasiia Yurevna Meglei, Viktoriia Pavlovna Basina, Andrey Anatolevich Nedorubov, Andrey Vyacheslavovich Vasilyev, Timofei Evgenevich Grigoriev, Yuriy Dmitrievich Zagoskin, Sergei Nicolaevich Chvalun and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. [Application progress of collagen membranes in oral medicine].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Review
  7. Antisolvent 3D Printing of Gene-Activated Scaffolds for Bone Regeneration.International journal of molecular sciences · 2024
    Article
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Tatiana Borisovna BukharovaResearch Centre for Medical Genetics, 115478 Moscow, Russia.ORCID 0000-0003-0481-256X
Irina Alekseevna NedorubovaResearch Centre for Medical Genetics, 115478 Moscow, Russia.ORCID 0000-0001-8472-7116
Viktoria Olegovna MokrousovaResearch Centre for Medical Genetics, 115478 Moscow, Russia.
Anastasiia Yurevna MegleiResearch Centre for Medical Genetics, 115478 Moscow, Russia.
Viktoriia Pavlovna BasinaResearch Centre for Medical Genetics, 115478 Moscow, Russia.
Andrey Anatolevich NedorubovInstitute of Translational Medicine and Biotechnology and E.V. Borovsky Institute of Dentistry, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 119991 Moscow, Russia.ORCID 0000-0002-5915-7999
Andrey Vyacheslavovich VasilyevResearch Centre for Medical Genetics, 115478 Moscow, Russia.ORCID 0000-0002-7169-2724
Timofei Evgenevich GrigorievNRC "Kurchatov Institute", 123182 Moscow, Russia.
Yuriy Dmitrievich ZagoskinNRC "Kurchatov Institute", 123182 Moscow, Russia.
Sergei Nicolaevich ChvalunNRC "Kurchatov Institute", 123182 Moscow, Russia.
Sergey Ivanovich KutsevResearch Centre for Medical Genetics, 115478 Moscow, Russia.
Dmitry Vadimovich GoldshteinResearch Centre for Medical Genetics, 115478 Moscow, Russia.
Research Centre for Medical Genetics · RUKurchatov Institute · RUSechenov University · RU

Funding

Ministry of Science and Higher Education of the Russian Federation for NRC Kurchatov Institute state assignmentMinistry of Science and Higher Education of the Russian Federation for RCMG State assignmentRussian Science Foundation 21-75-10147
6 · The paper itself

Abstract

Adenovirus-mediated gene therapy is a promising tool in bone regenerative medicine. In this work, gene-activated matrices (GAMs) composed of (1) polylactide granules (PLA), which serve as a depot for genetic constructs or matrices for cell attachment, (2) a PRP-based fibrin clot, which is a source of growth factors and a binding gel, and (3) a

Indexed as

AdenoviridaeOsteogenesisBone RegenerationFibrinGenetic TherapyFibrinadenoviral transductionbone regenerationgene therapymesenchymal stem cellsplatelet rich plasmapolylactide granules

Identifiers

PMID37443796
PMCPMC10340163
OpenAlexW4382982437

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.