Evidence map›Paper›PMID 37443751›Full record

ArticleCells2023

3'UTR of mRNA Encoding CPEB Protein Orb2 Plays an Essential Role in Intracellular Transport in Neurons.

Eugene N Kozlov, Roman V Deev, Elena V Tokmatcheva, Anna Tvorogova, Zaur M Kachaev, Rudolf A Gilmutdinov, Mariya Zhukova, Elena V Savvateeva-Popova, Paul Schedl, Yulii V Shidlovskii

Open access · goldAbstract read
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Role of CPEBs in Learning and Memory.Journal of neurochemistry · 2025
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Eugene N KozlovLaboratory of Gene Expression Regulation in Development, Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia.ORCID 0000-0002-8156-6959
Roman V DeevLaboratory of Gene Expression Regulation in Development, Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia.
Elena V TokmatchevaInstitute of Physiology, Russian Academy of Sciences, 188680 St. Petersburg, Russia.
Anna TvorogovaCenter for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia.
Zaur M KachaevLaboratory of Gene Expression Regulation in Development, Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia.ORCID 0000-0002-3866-0798
Rudolf A GilmutdinovLaboratory of Gene Expression Regulation in Development, Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia.
Mariya ZhukovaLaboratory of Gene Expression Regulation in Development, Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia.
Elena V Savvateeva-PopovaInstitute of Physiology, Russian Academy of Sciences, 188680 St. Petersburg, Russia.
Paul SchedlLaboratory of Gene Expression Regulation in Development, Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia.
Yulii V ShidlovskiiLaboratory of Gene Expression Regulation in Development, Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia.ORCID 0000-0002-3643-9889
Institute of Gene Biology · RUPavlov Institute of Physiology of the Russian Academy of Sciences · RUPrinceton University · USSechenov University · RU

Funding

Genetic regulatory mechanism in development and differentiationR35GM126975 · NIGMS · PRINCETON UNIVERSITY · PI SCHEDL, PAUL D · 2018 to 2022
$3.0M
NIGMS NIH HHS R35 GM126975Russian Science Foundation 18-74-10051
6 · The paper itself

Abstract

Intracellular trafficking plays a critical role in the functioning of highly polarized cells, such as neurons. Transport of mRNAs, proteins, and other molecules to synaptic terminals maintains contact between neurons and ensures the transmission of nerve impulses. Cytoplasmic polyadenylation element binding (CPEB) proteins play an essential role in long-term memory (LTM) formation by regulating local translation in synapses. Here, we show that the 3'UTR of the

Indexed as

Carrier ProteinsDrosophila Proteins3' Untranslated RegionsAnimalsDrosophilamRNA Cleavage and Polyadenylation FactorsNeuronsPolyadenylationRNA, Messenger3' Untranslated RegionsCarrier ProteinsDrosophila ProteinsmRNA Cleavage and Polyadenylation FactorsRNA, Messenger3′-untranslated regionCPEB proteinslong-term memorymRNA localization

Identifiers

PMID37443751
PMCPMC10340461
OpenAlexW4382136926

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.