Evidence map›Paper›PMID 37443603›Full record

ReviewDiagnostics (Basel, Switzerland)2023

Advancing HIV Drug Resistance Technologies and Strategies: Insights from South Africa's Experience and Future Directions for Resource-Limited Settings.

Kim Steegen, Gert U van Zyl, Mathilda Claassen, Aabida Khan, Melendhran Pillay, Subitha Govender, Phillip A Bester, Johanna M van Straaten, Vibha Kana, Ewaldé Cutler and 4 more

Abstract readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kim SteegenDepartment of Molecular Medicine and Haematology, National Health Laboratory Service, Charlotte Maxeke Johannesburg Hospital, Johannesburg 2193, South Africa.ORCID 0000-0003-3226-7685
Gert U van ZylDivision of Medical Virology, Stellenbosh University, Stellenbosh 7602, South Africa.ORCID 0000-0003-3021-5101
Mathilda ClaassenDivision of Medical Virology, Stellenbosh University, Stellenbosh 7602, South Africa.ORCID 0000-0002-6308-4438
Aabida KhanDepartment of Virology, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban 4041, South Africa.ORCID 0000-0002-8738-1867
Melendhran PillayDepartment of Virology, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban 4041, South Africa.
Subitha GovenderDepartment of Virology, National Health Laboratory Service, Inkosi Albert Luthuli Central Hospital, Durban 4058, South Africa.
Phillip A BesterDepartment of Medical Microbiology and Virology, University of the Free State, Bloemfontein 9300, South Africa.
Johanna M van StraatenDepartment of Medical Microbiology and Virology, National Health Laboratory Service, Universitas Academic Hospital, Bloemfontein 9301, South Africa.
Vibha KanaCentre for HIV and STIs, National Institute for Communicable Diseases, Johannesburg 2192, South Africa.
Ewaldé CutlerCentre for HIV and STIs, National Institute for Communicable Diseases, Johannesburg 2192, South Africa.
Monalisa N KalimasheCentre for HIV and STIs, National Institute for Communicable Diseases, Johannesburg 2192, South Africa.
Ramokone L LebeloDepartment of Virological Pathology, Sefako Makgatho Health Sciences University, Pretoria 0204, South Africa.ORCID 0000-0002-9365-514X
Mokopi B H MoloiDepartment of Virological Pathology, Sefako Makgatho Health Sciences University, Pretoria 0204, South Africa.
Lucia HansDepartment of Molecular Medicine and Haematology, National Health Laboratory Service, Charlotte Maxeke Johannesburg Hospital, Johannesburg 2193, South Africa.ORCID 0000-0002-0330-4857

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monitoring of HIV drug resistance (HIVDR) remains critical for ensuring countries attain and sustain the global goals for ending HIV as a public health threat by 2030. On an individual patient level, drug resistance results assist in ensuring unnecessary treatment switches are avoided and subsequent regimens are tailored on a case-by-case basis, should resistance be detected. Although there is a disparity in access to HIVDR testing in high-income countries compared to low- and middle-income countries (LMICS), more LMICs have now included HIVDR testing for individual patient management in some groups of patients. In this review, we describe different strategies for surveillance as well as where HIVDR testing can be implemented for individual patient management. In addition, we briefly review available technologies for HIVDR testing in LMICs, including Sanger sequencing, next-generation sequencing, and some point-of-care options. Finally, we describe how South Africa has implemented HIVDR testing in the public sector.

Indexed as

acquired drug resistanceHIV drug resistance testingnext-generation sequencingpretreatment drug resistancesurveillance

Identifiers

PMID37443603
PMCPMC10340187

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.