Evidence map›Paper›PMID 37443531›Full record

ArticleDiagnostics (Basel, Switzerland)2023

Medication-Related Osteonecrosis of the Jaws: A Comparison of SICMF-SIPMO and AAOMS Guidelines.

Davide De Cicco, Ciro Emiliano Boschetti, Mario Santagata, Giuseppe Colella, Samuel Staglianò, Alexander Gaggl, Gian Battista Bottini, Rita Vitagliano, Salvatore D'amato

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Post-COVID-19 Jaw Osteonecrosis: A Narrative Review.Medicina (Kaunas, Lithuania) · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Long-Term Efficacy and Safety of Denosumab: Insights beyond 10 Years of Use.Endocrinology and metabolism (Seoul, Korea) · 2025
    Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Davide De CiccoDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples "Federico II", 80131 Naples, Italy.ORCID 0000-0003-4363-388X
Ciro Emiliano BoschettiDepartment of Multidisciplinary Medical, Surgical and Dental Specialties, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Mario SantagataDepartment of Multidisciplinary Medical, Surgical and Dental Specialties, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0002-5657-2329
Giuseppe ColellaDepartment of Multidisciplinary Medical, Surgical and Dental Specialties, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0003-4197-9617
Samuel StaglianòDepartment of Multidisciplinary Medical, Surgical and Dental Specialties, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Alexander GagglDepartment of Oral and Craniomaxillofacial Surgery, Paracelsus Medical University, 5020 Salzburg, Austria.
Gian Battista BottiniDepartment of Oral and Craniomaxillofacial Surgery, Paracelsus Medical University, 5020 Salzburg, Austria.
Rita VitaglianoDepartment of Multidisciplinary Medical, Surgical and Dental Specialties, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0002-1920-2679
Salvatore D'amatoDepartment of Multidisciplinary Medical, Surgical and Dental Specialties, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0001-8030-4933
University of Campania "Luigi Vanvitelli" · ITParacelsus Medical University · ATUniversity of Naples Federico II · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: Medication-related osteonecrosis of the jaws (MRONJ) is an adverse drug reaction characterized by progressive bone disruption and necrosis in the mandibular and/or maxillary bones. It occurs in individuals who have received antiresorptive drugs without prior radiotherapy. Since its first reported cases in the USA in 2003, extensive literature has emerged worldwide, leading to significant advancements in understanding MRONJ's pathogenesis and management. (2) Results: This article aims to compare the current national recommendations provided by the Italian Society of Maxillofacial Surgery (SICMF)/Italian Society of Oral Pathology and Medicine (SIPMO) and the American Association of Oral and Maxillofacial Surgeons (AAOMS). (3) Conclusions: Historically, the AAOMS advocated for a more conservative approach compared to the Italian guidelines. However, in their 2022 update, the AAOMS adopted a different perspective based on reported evidence, highlighting the advantages of early surgical treatment. Despite resolving some initial controversies, differences still exist between the two sets of recommendations, particularly regarding diagnosis and staging.

Indexed as

diagnosisguidelinesMRONJONJpreventiontreatment

Identifiers

PMID37443531
PMCPMC10340476
OpenAlexW4381617514

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.