ArticleBritish journal of cancer2023
The underestimated impact of excess body weight on colorectal cancer risk: Evidence from the UK Biobank cohort.
Article in British journal of cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- At what age should people with obesity start colorectal cancer screening?International journal of cancer · 2026Pooled it
- Role of body mass index and weight change in the risk of cancer: A systematic review and meta-analysis of 66 cohort studies.Journal of global health · 2024Pooled it
- Body Mass Index at Diagnosis, Prediagnostic Weight Loss, and Survival in Colorectal Cancer.JAMA network open · 2026Article
- Age- and sex-dependent associations of metabolic syndrome with colorectal cancer in the UK Biobank.British journal of cancer · 2026Article
- Epigenetic indicators of body mass predict survival outcomes in colorectal cancer patients: patient cohort analysis.Genome medicine · 2026Article
- A nomogram based on body composition and the prognostic nutritional index to predict early postoperative complications of colorectal cancer.BMC medical imaging · 2026Article
- Myosteatosis mediates the link between specific dietary components and colorectal carcinogenesis: from PPLSS multi-center study.Asia Pacific journal of clinical nutrition · 2026Article
- Multifaceted Role of Quercetin in Colorectal Cancer: An Integrative Review on Adipose Tissue Modulation and Direct Anti-tumor Mechanisms.Chinese journal of integrative medicine · 2026Review
- Evaluating Risk Factors for Early-Onset Colorectal Cancer in a Large, Prospective Cohort.Digestive diseases and sciences · 2025Article
- Association of childhood-to-adulthood body size change with cancer risk: UK Biobank prospective cohort.BMC medicine · 2025Article
- Global burden of colon and rectal cancer and attributable risk factors in 204 countries and territories from 1990 to 2021.BMC gastroenterology · 2025Article
- To what extent is the association between obesity and colorectal cancer risk mediated by systemic inflammation?Cancer communications (London, England) · 2025Article
- Colorectal Cancer and Central Obesity.JAMA network open · 2025Article
- Global, Regional, and National Disease Burden and Prediction Analysis of Colorectal Cancer Attributable to Tobacco, Alcohol, and Obesity From 1990 to 2030.Frontiers in oncology · 2025Article
- Rising colorectal cancer burden attributable to high body mass index in China from 1990 to 2021: a comprehensive analysis using the global burden of disease study.Frontiers in endocrinology · 2025Article
- Overcoming underestimation of the share of colorectal cancer cases attributable to excess weight: a population-based study.Obesity (Silver Spring, Md.) · 2025Article
- Review
- A Review Article: The Relationship Between Obesity and Colorectal Cancer.Current diabetes reports · 2024Review
- Reevaluating the fraction of cancer attributable to excess weight: overcoming the hidden impact of prediagnostic weight loss.European journal of epidemiology · 2024Article
- Mendelian randomization unraveled: gender-specific insights into obesity-related phenotypes and colorectal cancer susceptibility.Frontiers in endocrinology · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe association between excess weight and colorectal cancer (CRC) risk may have been underestimated due to potential weight loss during pre-clinical sojourn time of CRC. We aimed to investigate this association and the corresponding population attributable fraction (PAF), accounting for prediagnostic weight loss.
methodsData from the UK Biobank prospective cohort were used. Multivariable adjusted hazard ratios (HR) and their 95% confidence intervals (CI) for various periods of follow-up and the corresponding PAF of excess weight were calculated.
resultsDuring a median of 10.0 years of follow-up, of 453,049 participants, 4794 developed CRC. The excess weight-CRC association became substantially stronger with including increasing lengths of follow-up in the analyses and further excluding the initial years of follow-up. HRs (95% CIs) for overweight and obesity were 1.06 (0.97-1.16) and 1.14 (1.03-1.26) after 7 years of follow-up, 1.13 (1.05-1.21) and 1.23 (1.14-1.33) when including complete follow-up length, and 1.26 (1.12-1.43) and 1.42 (1.24-1.63) when excluding the initial 7 years of follow-up. The corresponding PAFs of excess weight were estimated as 6.8%, 11.3%, and 19.0%, respectively.
conclusionsComprehensive consideration of the potential effect of prediagnostic weight loss discloses a much stronger impact of excess body weight on CRC risk than previously assumed.
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