Observational studyPediatric research2023
Changes in inflammatory proteins following platelet transfusion in a neonatal population.
Observational study in Pediatric research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Advanced Proteomic Profiling Demonstrates Clinical Utility of Patient-Centric, at-Home Dried Blood Sample Collection.Journal of proteome research · 2026Article
- Understanding the effects of platelet transfusions in neonates.Pediatric research · 2026Article
- Effects of platelet transfusions on neonatal bleeding and inflammation.Pediatric research · 2026Article
- Decreasing packed red blood cell (pRBC) transfusions in neonates through quality improvement.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Development and implementation of restrictive platelet transfusion thresholds in a neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Immune response to platelet transfusions.Current opinion in hematology · 2025Review
- Impact of platelet transfusions on plasma proteomes in controlled endotoxemia and in hemato-oncological patients.Transfusion · 2025Article
- Article
- Platelets in infection: intrinsic roles and functional outcomes.Frontiers in immunology · 2025Review
- Platelet transfusion in neonatal intensive care units of 22 European countries: a prospective observational study.The Lancet regional health. Europe · 2024Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStudies have demonstrated increased morbidity and mortality with platelet transfusions in the neonatal period. Platelets are as important for host immunity and inflammation as for hemostasis. Increased inflammation may explain the dose-associated increase in mortality, bleeding, and lung disease.
objectiveThis study aims to assess if there are any changes in inflammatory cytokines post-platelet transfusion in babies in NICU.
methodsThis prospective observational study recruited babies due to receive a non-emergency platelet transfusion. Dried whole blood samples were collected prior to and 2 h post-transfusion. Samples were processed using multiplex immunoassay to enable analysis of tiny blood volumes. Statistical analysis was performed using R.
resultsSeventeen babies underwent 26 platelet transfusions across two centers. Median birthweight was 1545 g (535-3960 g) and median birth gestation was 31 weeks and 1 day (23 + 1 to 40 + 5). Median pre-transfusion platelet count was 19.5 × 10
conclusionThe increase in the cytokines CXCL5, CD40 and TGF-β after platelet transfusion in babies in NICU could potentiate existing inflammation, NEC, lung, or white matter injury. This could potentially explain long-term harm from platelet transfusion in babies. IMPACT: There is a change in levels of immunomodulatory proteins CXCL5, CD40, and TGF-β after platelet transfusion in babies in NICU. Murine neonatal models have demonstrated an increase in cytokine levels after platelet transfusions. This is the first time that this has been demonstrated in human neonates. The increase in proinflammatory cytokines could potentially explain the long-term harm from platelet transfusion in babies, as they could potentiate existing inflammation, NEC, lung injury, or white matter injury.
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