ArticleNature chemistry2023
Thiophosphate photochemistry enables prebiotic access to sugars and terpenoid precursors.
Article in Nature chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 22 citations in OpenAlex.
- Chemical Routes to Primitive Membranes: Prebiotic Lipid Formation at the Origin of Life.Life (Basel, Switzerland) · 2026Review
- A scope of prebiotic neat reaction conditions and the mechanism of urea-assisted phosphorylations of alcohols.Nature communications · 2025Article
- Probing the Rydbergization of Water through the Stabilization Method.ACS physical chemistry Au · 2025Article
- Stabilization Method as a Tool for Electronic State Spectroscopy.The journal of physical chemistry. A · 2025Article
- Prebiotic thiol-catalyzed thioamide bond formation.Geochemical transactions · 2024Article
- Ring Opening of Glycerol Cyclic Phosphates Leads to a Diverse Array of Potentially Prebiotic Phospholipids.Journal of the American Chemical Society · 2023Article
- Carbonyl Migration in Uronates Affords a Potential Prebiotic Pathway for Pentose Production.JACS Au · 2023Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Over the past few years, evidence has accrued that demonstrates that terrestrial photochemical reactions could have provided numerous (proto)biomolecules with implications for the origin of life. This chemistry simply relies on UV light, inorganic sulfur species and hydrogen cyanide. Recently, we reported that, under the same conditions, reduced phosphorus species, such as those delivered by meteorites, can be oxidized to orthophosphate, generating thiophosphate in the process. Here we describe an investigation of the properties of thiophosphate as well as additional possible means for its formation on primitive Earth. We show that several reported prebiotic reactions, including the photoreduction of thioamides, carbonyl groups and cyanohydrins, can be markedly improved, and that tetroses and pentoses can be accessed from hydrogen cyanide through a Kiliani-Fischer-type process without progressing to higher sugars. We also demonstrate that thiophosphate allows photochemical reductive aminations, and that thiophosphate chemistry allows a plausible prebiotic synthesis of the C
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