ArticleNature neuroscience2023
Using temperature to analyze the neural basis of a time-based decision.
Article in Nature neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Abstract Representation of Movement Parameters in Basal Ganglia Output.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Mild Focal Cooling Decouples Dendrites to Reconfigure Cortical Output.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Neural temporal scaling accounts for robust hunting behavior across temperatures.Nature communications · 2026Article
- Neural circuit models for evidence accumulation through choice-selective sequences.Nature communications · 2026Article
- Differential cannabinergic effects on temporal perception and production.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
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- GoFish: a foray into open-source, aquatic behavioral automation.Journal of fish biology · 2025Article
- Distinct neural population code and causal roles of primate caudate nucleus in multimodal decision-making.Nature communications · 2025Article
- The Role of Striatum in Controlling Waiting during Reactive and Self-Timed Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Medium Spiny Neurons Mediate Timing Perception in Coordination with Prefrontal Neurons in Primates.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Article
- Article
- Preconfigured cortico-thalamic neural dynamics constrain movement-associated thalamic activity.Nature communications · 2024Article
- Perturbation context in paced finger tapping tunes the error-correction mechanism.Scientific reports · 2024Article
- Mild focal cooling selectively impacts computations in dendritic trees.bioRxiv : the preprint server for biology · 2024Article
- Recent Advance in Synaptic Plasticity Modulation Techniques for Neuromorphic Applications.Nano-micro letters · 2024Review
- Nonlinear manifolds underlie neural population activity during behaviour.bioRxiv : the preprint server for biology · 2024Article
- Article
- Neural population clocks: Encoding time in dynamic patterns of neural activity.Behavioral neuroscience · 2022Article
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7 authors.
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Abstract
The basal ganglia are thought to contribute to decision-making and motor control. These functions are critically dependent on timing information, which can be extracted from the evolving state of neural populations in their main input structure, the striatum. However, it is debated whether striatal activity underlies latent, dynamic decision processes or kinematics of overt movement. Here, we measured the impact of temperature on striatal population activity and the behavior of rats, and compared the observed effects with neural activity and behavior collected in multiple versions of a temporal categorization task. Cooling caused dilation, and warming contraction, of both neural activity and patterns of judgment in time, mimicking endogenous decision-related variability in striatal activity. However, temperature did not similarly affect movement kinematics. These data provide compelling evidence that the timecourse of evolving striatal activity dictates the speed of a latent process that is used to guide choices, but not continuous motor control. More broadly, they establish temporal scaling of population activity as a likely neural basis for variability in timing behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.