Evidence map›Paper›PMID 37443276›Full record

ReviewNPJ digital medicine2023

Challenges of implementing computer-aided diagnostic models for neuroimages in a clinical setting.

Matthew J Leming, Esther E Bron, Rose Bruffaerts, Yangming Ou, Juan Eugenio Iglesias, Randy L Gollub, Hyungsoon Im

Open access · goldAbstract readReview
In one paragraph

Review in NPJ digital medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 42 citations in OpenAlex.

  1. Review
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  9. Article
  10. Differential dementia detection from multimodal brain images in a real-world dataset.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  11. Article
  12. Article
  13. It is Not Time to Kick Out Radiologists.Asian bioethics review · 2025
    Article
  14. Article
  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 4 countries.

Matthew J LemingCenter for Systems Biology, Massachusetts General Hospital, Boston, MA, USA. mleming@mgh.harvard.edu.ORCID http://orcid.org/0000-0001-9631-2567
Esther E BronDepartment of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-5778-9263
Rose BruffaertsComputational Neurology, Experimental Neurobiology Unit (ENU), Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Yangming OuBoston Children's Hospital, 300 Longwood Ave, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7726-6208
Juan Eugenio IglesiasCenter for Medical Image Computing, University College London, London, UK.
Randy L GollubDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9434-4044
Hyungsoon ImCenter for Systems Biology, Massachusetts General Hospital, Boston, MA, USA. im.hyungsoon@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-0626-1346
Harvard University · USMassachusetts General Hospital · USBoston Children's Hospital · USErasmus MC · NLUniversity of Antwerp · BE

Funding

Functionally guided adult whole brain cell atlas in human and NHPUM1MH130981 · NIMH · ALLEN INSTITUTE · PI Ed Lein, Hongkui Zeng · 2022 to 2026
$91.9M
Research Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI STEVEN E ARNOLD · 2019 to 2026
$36.5M
Portable, Low Field Brain Magnetic Resonance Imaging (MRI) for Acute StrokeR01EB031114 · NIBIB · YALE UNIVERSITY · PI William Taylor Kimberly, Matthew Scot Rosen · 2022 to 2026
$3.5M
Diagnosing the undiagnosable: studies of Alzheimer disease mimics and confounders via "neuropathometry" of dissection photos with 3D scanningR01AG070988 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI IGLESIAS GONZALEZ, JUAN EUGENIO · 2021 to 2025
$2.7M
Consortium Of MRI Biomarkers In Neonatal Encephalopathy (COMBINE)R61NS126792 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI COTTEN, CHARLES MICHAEL, GRANT, PATRICIA ELLEN · 2022 to 2024
$2.7M
Development of plasmon-enhanced biosensing for multiplexed profiling of extracellular vesiclesR01GM138778 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI IM, HYUNGSOON · 2020 to 2024
$2.3M
Open-source software for multi-scale mapping of the human brainRF1MH123195 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI FISCHL, BRUCE, IGLESIAS GONZALEZ, JUAN EUGENIO · 2020 to 2020
$2.0M
Consortium Of MRI Biomarkers In Neonatal Encephalopathy (COMBINE)R33NS126792 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI CHARLES Michael COTTEN, Patricia Ellen Grant · 2025 to 2026
$1.8M
Neural Substrate of Outcomes after Neonatal Hypoxic Ischemic EncephalopathyR21NS121735 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI OU, YANGMING · 2022 to 2023
$504k
Brain MRI to pre-symptomatically predict seizure onset for Sturge-Weber SyndromeR21TR004265 · NCATS · BOSTON CHILDREN'S HOSPITAL · PI COMI, ANNE M, OU, YANGMING · 2022 to 2023
$479k
Multi-Site Clinical Data to Power MRI Biomarker of Neonatal Brain InjuryR03HD104891 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI OU, YANGMING · 2021 to 2022
$190k
Multi-site Data for Nutrition Studies in Healthy Early ChildhoodR03HD107124 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI OU, YANGMING · 2022 to 2023
$177k
NCATS NIH HHS R21 TR004265NIA NIH HHS P30 AG062421NIA NIH HHS R01 AG070988NIBIB NIH HHS R01 EB031114NICHD NIH HHS R03 HD104891NICHD NIH HHS R03 HD107124NIGMS NIH HHS R01 GM138778NIMH NIH HHS RF1 MH123195NIMH NIH HHS UM1 MH130981NINDS NIH HHS R21 NS121735NINDS NIH HHS R33 NS126792NINDS NIH HHS R61 NS126792
6 · The paper itself

Abstract

Advances in artificial intelligence have cultivated a strong interest in developing and validating the clinical utilities of computer-aided diagnostic models. Machine learning for diagnostic neuroimaging has often been applied to detect psychological and neurological disorders, typically on small-scale datasets or data collected in a research setting. With the collection and collation of an ever-growing number of public datasets that researchers can freely access, much work has been done in adapting machine learning models to classify these neuroimages by diseases such as Alzheimer's, ADHD, autism, bipolar disorder, and so on. These studies often come with the promise of being implemented clinically, but despite intense interest in this topic in the laboratory, limited progress has been made in clinical implementation. In this review, we analyze challenges specific to the clinical implementation of diagnostic AI models for neuroimaging data, looking at the differences between laboratory and clinical settings, the inherent limitations of diagnostic AI, and the different incentives and skill sets between research institutions, technology companies, and hospitals. These complexities need to be recognized in the translation of diagnostic AI for neuroimaging from the laboratory to the clinic.

Identifiers

PMID37443276
PMCPMC10345121
OpenAlexW4384154784

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.