ArticleHypertension research : official journal of the Japanese Society of Hypertension2023
Causal effect of hypertension and blood pressure on aortic diseases: evidence from Mendelian randomization.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 12 citations in OpenAlex.
- Gastroesophageal reflux disease and childhood asthma: A bidirectional two-sample Mendelian randomization study.Medicine · 2026Article
- Association Between Diet Quality, Physical Activity, and the Risk of Aortic Dissection-A Prospective Cohort Study.Journal of cardiovascular development and disease · 2026Article
- Predictive value of preoperative neutrophil-to-lymphocyte ratio for prognosis in aortic dissection patients without hypertension following TEVAR.Frontiers in aging · 2026Article
- Evaluation of aortic stiffness with an oscillometric arteriograph device in patients with hypertension and ascending aortic aneurysm.Revista da Associacao Medica Brasileira (1992) · 2026Article
- Integrated metabolomics and lipidomics reveal fatty acid dysregulation in aortic dissection independent of hypertension.Scientific reports · 2025Article
- Blood pressure, hypertension, and the risk of aortic aneurysm in the UK Biobank.BMC cardiovascular disorders · 2025Article
- Contextualizing molecular and structural aging across human organs.medRxiv : the preprint server for health sciences · 2025Article
- Chest x-ray aortic size and risk of death and cardiovascular disease in older Chinese: Guangzhou biobank cohort study.Journal of internal medicine · 2025Article
- Machine Learning Model for Predicting Risk Factors of Prolonged Length of Hospital Stay in Patients with Aortic Dissection: a Retrospective Clinical Study.Journal of cardiovascular translational research · 2025Article
- Aortic dissection induced by licorice tablets overdose: a Case Report.Frontiers in pharmacology · 2025Article
- Exploring the association between grip strength and adverse pregnancy and perinatal outcomes: A Mendelian randomization study.Heliyon · 2024Article
- Uncovering Druggable Targets in Aortic Dissection: An Association Study Integrating Mendelian Randomization, pQTL, and Protein-Protein Interaction Network.Biomedicines · 2024Article
- Potential of Current Direct Mechanical Testing Methods in Assessing Intraoperative Samples of Aortic Aneurysm Caused by Uncontrolled Arterial Hypertension.Sovremennye tekhnologii v meditsine · 2024Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypertension or elevated blood pressure was documented to be an important risk factor for aortic diseases in observational studies, yet the causality remains to be determined. By applying a two-sample Mendelian randomization (MR) approach, we aim to determine whether hypertension or elevated blood pressure (systolic blood pressure [SBP] or diastolic blood pressure [DBP]) is linked causally to aortic aneurysm or aortic dissection. Genetic instruments and summary statistics for hypertension and aortic diseases were obtained from large genome-wide association studies. The traditional inverse variance weighted (IVW) method was used to obtain the causal estimates. Sensitivity analyses including MR-Egger, weighted median and multivariable MR were also performed. Our results suggested that genetic liability to hypertension was associated with aortic dissection (odds ratio [OR]: 1.81; 95% confidence interval [CI]: 1.27-2.58; P = 1.13 × 10
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