ArticleNature communications2023
Label-free adaptive optics single-molecule localization microscopy for whole zebrafish.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Nanoscale magnesium hydride alleviates hypoxia-induced myelination deficits in zebrafish.Medical gas research · 2026Article
- Background-free quantitative phase imaging with adaptive-optics surface plasmon resonance holographic microscopy.Light, science & applications · 2026Article
- Dual deconvolution in multiphoton structured illumination microscopy for deep-tissue super-resolution imaging.Nature communications · 2026Article
- Review
- Perspective: An outlook on fluorescence tracking.The Journal of chemical physics · 2025Article
- Ultrasound matrix imaging for 3D transcranial in vivo localization microscopy.Science advances · 2025Article
- Adaptive optics in an oblique plane microscope.Biomedical optics express · 2024Article
- Adaptive Optics in an Oblique Plane Microscope.bioRxiv : the preprint server for biology · 2024Article
- Tracing multiple scattering trajectories for deep optical imaging in scattering media.Nature communications · 2023Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Specimen-induced aberration has been a major factor limiting the imaging depth of single-molecule localization microscopy (SMLM). Here, we report the application of label-free wavefront sensing adaptive optics to SMLM for deep-tissue super-resolution imaging. The proposed system measures complex tissue aberrations from intrinsic reflectance rather than fluorescence emission and physically corrects the wavefront distortion more than three-fold stronger than the previous limit. This enables us to resolve sub-diffraction morphologies of cilia and oligodendrocytes in whole zebrafish as well as dendritic spines in thick mouse brain tissues at the depth of up to 102 μm with localization number enhancement by up to 37 times and localization precision comparable to aberration-free samples. The proposed approach can expand the application range of SMLM to whole zebrafish that cause the loss of localization number owing to severe tissue aberrations.
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Registered trials
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