ArticleNature communications2023
Genes associated with cognitive ability and HAR show overlapping expression patterns in human cortical neuron types.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Gene expression dynamics of human and mouse craniofacial development at the single-cell level.Nature communications · 2026Article
- Human Neocortical Glutamatergic Neurons Revealed Through Multimodal Profiling.bioRxiv : the preprint server for biology · 2026Article
- A phenotypic brain organoid atlas and biobank for neurodevelopmental disorders.Cell stem cell · 2025Article
- Multivariate genome-wide analysis reveals shared genetic architecture and brain structural correlates of human cognitive abilities.Scientific reports · 2025Article
- Genetic Foundations of Inter-individual Neurophysiological Variability.bioRxiv : the preprint server for biology · 2025Article
- Gene expression patterns of the developing human face at single cell resolution reveal cell type contributions to normal facial variation and disease risk.bioRxiv : the preprint server for biology · 2025Article
- Identification ofProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Exploring gene expression in the maturing human brain at the single-cell level.Nature genetics · 2024Article
- A temporal cortex cell atlas highlights gene expression dynamics during human brain maturation.Nature genetics · 2024Article
- Human-specific genetic modifiers of cortical architecture and function.Current opinion in genetics & development · 2024Review
- Evolutionary perspectives on mRNA signatures of neurodegeneration-related brain remodelling.Brain : a journal of neurology · 2024Article
- Cell type-specific gene expression dynamics during human brain maturation.bioRxiv : the preprint server for biology · 2024Article
- Genes associated with cognitive ability and HAR show overlapping expression patterns in human cortical neuron types.Nature communications · 2023Article
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Authors and funding
20 authors at 3 institutions in 2 countries.
Funding
Abstract
GWAS have identified numerous genes associated with human cognition but their cell type expression profiles in the human brain are unknown. These genes overlap with human accelerated regions (HARs) implicated in human brain evolution and might act on the same biological processes. Here, we investigated whether these gene sets are expressed in adult human cortical neurons, and how their expression relates to neuronal function and structure. We find that these gene sets are preferentially expressed in L3 pyramidal neurons in middle temporal gyrus (MTG). Furthermore, neurons with higher expression had larger total dendritic length (TDL) and faster action potential (AP) kinetics, properties previously linked to intelligence. We identify a subset of genes associated with TDL or AP kinetics with predominantly synaptic functions and high abundance of HARs.
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