Evidence map›Paper›PMID 37443101›Full record

ReviewMilitary Medical Research2023

Activatable fluorescent probes for imaging and diagnosis of rheumatoid arthritis.

Pan Luo, Fu-Qiang Gao, Wei Sun, Jun-You Li, Cheng Wang, Qing-Yu Zhang, Zhi-Zhuo Li, Peng Xu

Open access · diamondAbstract readReview
In one paragraph

Review in Military Medical Research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 3 countries.

Pan Luo *Department of Joint Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, 710054, China.
Fu-Qiang Gao *Department of Orthopedics, China-Japan Friendship Hospital, Beijing, 100029, China.
Wei SunDepartment of Orthopaedic Surgery of the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Jun-You LiSchool of Mechanical Engineering, Sungkyunkwan University, Suwon, 16419, South Korea.
Cheng WangDepartment of Orthopaedic Surgery, Peking University Third Hospital, Peking University, Beijing, 100191, China.
Qing-Yu ZhangDepartment of Orthopedics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, China.
Zhi-Zhuo LiState Key Laboratory of Pharmaceutical Biotechnology, Division of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, China.
Peng XuDepartment of Joint Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, 710054, China. xupeng369@mail.xjtu.edu.cn.ORCID 0000-0003-2487-9163
Xi'an Honghui Hospital · CNChina-Japan Friendship Hospital · CNNanjing Drum Tower Hospital · CNPeking University · CNShandong Provincial Hospital · CNSungkyunkwan University · KRUniversity of Pennsylvania · US

Funding

Elite Medical Professionals project of China-Japan Friendship Hospita ZRJY2021-GG12National Natural Science Foundation of China 82072432the China-Japan Friendship Hospital Horizontal Project/Spontaneous Research Funding 2022-HX-JC-7the National High Level Hospital Clinical Research Funding 2022-NHLHCRF-PY-20
6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is a systemic autoimmune disease that is primarily manifested as synovitis and polyarticular opacity and typically leads to serious joint damage and irreversible disability, thus adversely affecting locomotion ability and life quality. Consequently, good prognosis heavily relies on the early diagnosis and effective therapeutic monitoring of RA. Activatable fluorescent probes play vital roles in the detection and imaging of biomarkers for disease diagnosis and in vivo imaging. Herein, we review the fluorescent probes developed for the detection and imaging of RA biomarkers, namely reactive oxygen/nitrogen species (hypochlorous acid, peroxynitrite, hydroxyl radical, nitroxyl), pH, and cysteine, and address the related challenges and prospects to inspire the design of novel fluorescent probes and the improvement of their performance in RA studies.

Indexed as

Arthritis, RheumatoidSynovitisBiomarkersFluorescent DyesHumansReactive Nitrogen SpeciesReactive Oxygen SpeciesBiomarkersFluorescent DyesReactive Nitrogen SpeciesReactive Oxygen SpeciesBiomarkerDiagnosisFluorescent probeImagingRheumatoid arthritis

Identifiers

PMID37443101
PMCPMC10347857
OpenAlexW4384276954

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.