Evidence map›Paper›PMID 37443093›Full record

ArticleThyroid research2023

Decrease of thyroid function after ischemic stroke is related to stroke severity.

Evgeny Sidorov, Aruna Paul, Chao Xu, Claire Delpirou Nouh, Allshine Chen, Albina Gosmanova, Niyaz Gosmanov, David Lee Gordon, Irina Baranskaya, Juliane Chainakul and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thyroid research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Observational
  4. Observational
  5. Autonomic dysfunction after stroke: an overview of recent clinical evidence and perspectives on therapeutic management.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Evgeny SidorovDepartment of Neurology, University of Oklahoma Health Sciences Center, 920 Stanton L. Young Blvd #2040, Oklahoma City, OK, 73104, USA. evgeny-sidorov@ouhsc.edu.ORCID http://orcid.org/0000-0003-0307-5828
Aruna PaulDepartment of Neurology, University of Oklahoma Health Sciences Center, 920 Stanton L. Young Blvd #2040, Oklahoma City, OK, 73104, USA.
Chao XuDepartment of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, 801 N.E. 13Th Street, Oklahoma City, OK, 73104, USA.ORCID http://orcid.org/0000-0002-3821-6187
Claire Delpirou NouhDepartment of Neurology, University of Oklahoma Health Sciences Center, 920 Stanton L. Young Blvd #2040, Oklahoma City, OK, 73104, USA.ORCID http://orcid.org/0000-0002-8146-9702
Allshine ChenDepartment of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, 801 N.E. 13Th Street, Oklahoma City, OK, 73104, USA.
Albina GosmanovaDepartment of Medicine, Section of Endocrinology, Diabetes and Metabolism, University of Oklahoma Health Sciences Center, 1000 N. Lincoln Blvd, Oklahoma City, OK, 73104, USA.
Niyaz GosmanovDepartment of Medicine, Section of Endocrinology, Diabetes and Metabolism, University of Oklahoma Health Sciences Center, 1000 N. Lincoln Blvd, Oklahoma City, OK, 73104, USA.
David Lee GordonDepartment of Neurology, University of Oklahoma Health Sciences Center, 920 Stanton L. Young Blvd #2040, Oklahoma City, OK, 73104, USA.
Irina BaranskayaDepartment of Psychiatry, 920 Stanton L. Young Boulevard, G. Rainey Williams Pavilion, 3Rd Floor, Oklahoma City, OK, 73104, USA.
Juliane ChainakulDepartment of Neurology, University of Oklahoma Health Sciences Center, 920 Stanton L. Young Blvd #2040, Oklahoma City, OK, 73104, USA.
Robert HamiltonDepartment of Neurology, University of Oklahoma Health Sciences Center, 920 Stanton L. Young Blvd #2040, Oklahoma City, OK, 73104, USA.
Alexander MdzinarishviliDepartment of Neurology, University of Oklahoma Health Sciences Center, 920 Stanton L. Young Blvd #2040, Oklahoma City, OK, 73104, USA. Alexander-Mdzinarishvili@ouhsc.edu.
University of Oklahoma Health Sciences Center · USOklahoma City VA Medical Center · USCenter for Neurosciences · USOklahoma City University · USWilliams (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThyroid hormones are of fundamental importance for brain function. While low triiodothyronine levels during acute ischemic stroke (AIS) are associated with worse clinical outcomes, dynamics of thyroid function after AIS remains unknown. Thus, we longitudinally evaluated thyroid hormones after stroke and related them to stroke severity.

methodsWe prospectively traced thyroid stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxin (fT4) levels from the hyper-acute (within 24 h) to acute (3-5 days) and chronic (3-6 months) stages of ischemic stroke using a mixed regression model. Then, we analyzed whether stroke severity at presentation, expressed by National Institute of Health Stroke Scale (NIHSS), is associated with change in thyroid function.

resultsForty-five patients were evaluated in hyper-acute and acute stages, while 29 were followed through chronic stage. TSH levels decreased from hyper-acute (2.91 ± 0.65 μIU/mL) to acute (2.86 ± 0.46 μIU/mL) and chronic stages of stroke (1.93 ± 0.35 μIU/m, p = 0.95). fT3 levels decreased from hyper-acute (2.79 ± 0.09 pg/ml) to acute (2.37 ± 0.07 pg/ml) stages, but recovered in chronic stage (2.78 ± 0.10 pg/ml, p < 0.01). fT4 levels decreased from hyper-acute (1.64 ± 0.14 ng/dl) to acute (1.13 ± 0.03 ng/dl) stages, and increased in the chronic stage (1.16 ± 0.08 ng/dl, p = 0.02). One-unit increase in presenting NIHSS was associated with 0.04-unit decrease of fT3 from hyper-acute to the acute stage (p < 0.01).

conclusionThere is a transient decrease of thyroid hormones after ischemic stroke, possibly driven by stroke severity. Larger studies are needed to validate these findings. Correction of thyroid function in acute stroke may be investigated to improve stroke outcomes.

Indexed as

Acute ischemic strokeStroke severityThyroid hormonesThyroxinTriiodothyronine

Identifiers

PMID37443093
PMCPMC10339501
OpenAlexW4384203512

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.