Evidence map›Paper›PMID 37443063›Full record

ArticleSystematic reviews2023

Impact of iron supplementation on patient outcomes for women with abnormal uterine bleeding: a protocol for a systematic review and meta-analysis.

Hasmik Nazaryan, Megan Watson, Dana Ellingham, Swarni Thakar, Andrea Wang, Menaka Pai, Yang Liu, Bram Rochwerg, Nadia Gabarin, Donald Arnold and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Systematic reviews, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Hasmik Nazaryan *Michael G. DeGroote Centre for Transfusion Research, McMaster University, 1200 Main Street West HSC-3H50, Hamilton, ON, L8N 3Z5, Canada.
Megan Watson *Michael G. DeGroote Centre for Transfusion Research, McMaster University, 1200 Main Street West HSC-3H50, Hamilton, ON, L8N 3Z5, Canada.
Dana EllinghamMichael G. DeGroote Centre for Transfusion Research, McMaster University, 1200 Main Street West HSC-3H50, Hamilton, ON, L8N 3Z5, Canada.
Swarni ThakarMichael G. DeGroote Centre for Transfusion Research, McMaster University, 1200 Main Street West HSC-3H50, Hamilton, ON, L8N 3Z5, Canada.
Andrea WangDepartment of Medicine and Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Menaka PaiDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Yang LiuMichael G. DeGroote Centre for Transfusion Research, McMaster University, 1200 Main Street West HSC-3H50, Hamilton, ON, L8N 3Z5, Canada.
Bram RochwergDepartment of Medicine and Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Nadia GabarinDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Donald ArnoldMichael G. DeGroote Centre for Transfusion Research, McMaster University, 1200 Main Street West HSC-3H50, Hamilton, ON, L8N 3Z5, Canada.
Emily Sirotich *Michael G. DeGroote Centre for Transfusion Research, McMaster University, 1200 Main Street West HSC-3H50, Hamilton, ON, L8N 3Z5, Canada.
Michelle P Zeller *Michael G. DeGroote Centre for Transfusion Research, McMaster University, 1200 Main Street West HSC-3H50, Hamilton, ON, L8N 3Z5, Canada. zeller@mcmaster.ca.ORCID 0000-0002-6489-6980
McMaster University · CAImpact · CACanadian Blood Services · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAbnormal uterine bleeding (AUB), which includes heavy menstrual bleeding (HMB), is a common condition placing women at increased risk for developing iron deficiency and iron deficiency anemia (IDA). Depletion of iron stores has negative implications on physical, social, and emotional health, as well as quality of life. Iron supplements are safe, effective, and readily available, while red blood cell (RBC) transfusions have inherent risks including infectious and immune reactions. Despite high prevalence of IDA among women with AUB, there are limited studies on the impact of iron therapies on patient outcomes. This systematic review and meta-analysis will evaluate the impact of iron supplementation on patient outcomes for women with AUB, when compared to combination therapy, no intervention, placebo, or standard of care.

methodsWe will conduct a systematic review and meta-analysis of randomized controlled trials and observational studies evaluating the impact of iron interventions on patient outcomes for women with AUB. Systematic literature searches will be conducted in major databases including MEDLINE, EMBASE, CENTRAL, CINAHL, and Web of Science. Studies assessing the impact of iron interventions on patient outcomes in women experiencing AUB, in comparison to combination therapy, no intervention, placebo, or standard of care, will be included in the review. Independent reviewers will screen for eligibility, assess risk of bias, and abstract data. Overall certainty of evidence for each outcome will be assessed using the GRADE approach. We will meta-analyze outcomes which are sufficiently homogeneous to summarize intervention effects and narratively synthesize nonhomogeneous outcomes. The main outcomes of interest are hemoglobin levels immediately prior to surgery and post-operatively, number of RBC transfusions, and adverse effects. Secondary outcomes will include length of hospital stay, intraoperative blood loss, adverse and side effects, quality of life, and iron indices. DISCUSSION: This review will evaluate the impact of iron interventions on patient outcomes in women with IDA secondary to AUB with focus on changes in hematological and iron indices, red blood cell utilization, quality of life, cost of treatment, and adverse events. The results will inform evidence-based clinical practice for the management of iron deficiency and IDA secondary to AUB. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42019137282.

Indexed as

Anemia, Iron-DeficiencyIron DeficienciesDietary SupplementsFemaleHumansIronMeta-Analysis as TopicQuality of LifeReview Literature as TopicSystematic Reviews as TopicUterine HemorrhageIronAbnormal uterine bleedingHeavy menstrual bleedingIron deficiencyIron deficiency anemiaIron supplementationMenorrhagiaMeta-analysisRed blood cell transfusionSystematic review

Identifiers

PMID37443063
PMCPMC10347734
OpenAlexW4384277080

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.