ArticleBMC musculoskeletal disorders2023
Negative association between triglyceride glucose index and BMI-adjusted skeletal muscle mass index in hypertensive adults.
Article in BMC musculoskeletal disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 5 citations in OpenAlex.
- Association between C-reactive protein-triglyceride glucose index (CTI) and cardiovascular and all-cause mortality risk among the elderly population: insights from three datasets.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- TYG-BMI demonstrates modestly higher predictive value compared to TYG and TYG/HDL for cardiovascular disease incidence in individuals over 45: a longitudinal cohort study.Diabetology & metabolic syndrome · 2026Article
- Serum vitamin D levels and appendicular skeletal muscle index in United States adolescents: A cross-sectional study based on NHANES.Medicine · 2026Article
- Triglyceride-glucose index as a predictor of the risk of sarcopenia in elderly patients with OSA: a multicenter study.Diabetology & metabolic syndrome · 2025Article
- Evaluation of a Computed Tomography-based Technique for Predicting Atrial Fibrillation Recurrence Following Ablation Using an Adjusted Skeletal Muscle Index.Reviews in cardiovascular medicine · 2025Article
- Association between serum cotinine and muscle mass: results from NHANES 2011-2018.BMC public health · 2024Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe triglyceride glucose (TyG) index, an indicator of insulin resistance, is often associated with adverse outcomes in various cardiovascular diseases, while hypertension is associated with an increased risk of cardiovascular diseases. As the loss of muscle mass in people with hypertension is poorly understood, the current study aimed to explore the relationship between TyG index and muscle mass in hypertensive population.
methodsWe analyzed data from hypertensive adult participants in the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018. The TyG index and body mass index (BMI)-adjusted skeletal muscle mass index (SMI) were calculated and the relationship between the two was evaluated using multivariable linear regression and restricted cubic spline (RCS) regression models.
resultsA total of 1633 participants in the dataset were included for the final analysis. In the multivariable regression analysis, the adjusted β of SMI with a 95% confidence interval (CI) for the highest TyG index quartile was - 5.27 (- 9.79 to - 0.75), compared with the lowest quartile. A negative linear relationship between TyG index and SMI was plotted by RCS regression (nonlinear P = 0.128). Stratified models of non-smoking women of different ages also demonstrated that SMI decreased as TyG index increased (all P for trend < 0.05).
conclusionThis linear and negative correlation between TyG index and SMI in hypertensive patients suggests that insulin resistance adversely affects muscle mass.
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