Evidence map›Paper›PMID 37442623›Full record

ArticleNeurology2023

Demographic, Medical, and Clinical Characteristics of a Population-Based Sample of Patients With Long-lasting Locked-In Syndrome.

Helle Walseth Nilsen, Anne Catrine T Martinsen, Inger Johansen, Marit Kirkevold, Katharina Stibrant Sunnerhagen, Frank Becker

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Helle Walseth NilsenFrom the Sunnaas Rehabilitation Hospital (H.W.N., A.C.T.M., F.B.), Nesoddtangen; Institute of Clinical Medicine (H.W.N., F.B.), University of Oslo; Department of Radiology (A.C.T.M.), Oslo Metropolitan University; Institute of Health and Society (I.J.), University of Oslo; Department of Nursing and Health Promotion (M.K.), Oslo Metropolitan University, Norway; Department of Clinical Neuroscience (K.S.S.), University of Gothenburg; and Neurocare (K.S.S.), Sahlgrenska University Hospital, Gothenburg, Sweden.
Anne Catrine T MartinsenFrom the Sunnaas Rehabilitation Hospital (H.W.N., A.C.T.M., F.B.), Nesoddtangen; Institute of Clinical Medicine (H.W.N., F.B.), University of Oslo; Department of Radiology (A.C.T.M.), Oslo Metropolitan University; Institute of Health and Society (I.J.), University of Oslo; Department of Nursing and Health Promotion (M.K.), Oslo Metropolitan University, Norway; Department of Clinical Neuroscience (K.S.S.), University of Gothenburg; and Neurocare (K.S.S.), Sahlgrenska University Hospital, Gothenburg, Sweden.ORCID 0000-0002-1346-7721
Inger JohansenFrom the Sunnaas Rehabilitation Hospital (H.W.N., A.C.T.M., F.B.), Nesoddtangen; Institute of Clinical Medicine (H.W.N., F.B.), University of Oslo; Department of Radiology (A.C.T.M.), Oslo Metropolitan University; Institute of Health and Society (I.J.), University of Oslo; Department of Nursing and Health Promotion (M.K.), Oslo Metropolitan University, Norway; Department of Clinical Neuroscience (K.S.S.), University of Gothenburg; and Neurocare (K.S.S.), Sahlgrenska University Hospital, Gothenburg, Sweden.ORCID 0000-0003-3446-6426
Marit KirkevoldFrom the Sunnaas Rehabilitation Hospital (H.W.N., A.C.T.M., F.B.), Nesoddtangen; Institute of Clinical Medicine (H.W.N., F.B.), University of Oslo; Department of Radiology (A.C.T.M.), Oslo Metropolitan University; Institute of Health and Society (I.J.), University of Oslo; Department of Nursing and Health Promotion (M.K.), Oslo Metropolitan University, Norway; Department of Clinical Neuroscience (K.S.S.), University of Gothenburg; and Neurocare (K.S.S.), Sahlgrenska University Hospital, Gothenburg, Sweden.ORCID 0000-0002-3979-0631
Katharina Stibrant SunnerhagenFrom the Sunnaas Rehabilitation Hospital (H.W.N., A.C.T.M., F.B.), Nesoddtangen; Institute of Clinical Medicine (H.W.N., F.B.), University of Oslo; Department of Radiology (A.C.T.M.), Oslo Metropolitan University; Institute of Health and Society (I.J.), University of Oslo; Department of Nursing and Health Promotion (M.K.), Oslo Metropolitan University, Norway; Department of Clinical Neuroscience (K.S.S.), University of Gothenburg; and Neurocare (K.S.S.), Sahlgrenska University Hospital, Gothenburg, Sweden.ORCID 0000-0002-5940-4400
Frank BeckerFrom the Sunnaas Rehabilitation Hospital (H.W.N., A.C.T.M., F.B.), Nesoddtangen; Institute of Clinical Medicine (H.W.N., F.B.), University of Oslo; Department of Radiology (A.C.T.M.), Oslo Metropolitan University; Institute of Health and Society (I.J.), University of Oslo; Department of Nursing and Health Promotion (M.K.), Oslo Metropolitan University, Norway; Department of Clinical Neuroscience (K.S.S.), University of Gothenburg; and Neurocare (K.S.S.), Sahlgrenska University Hospital, Gothenburg, Sweden. frank.becker@sunnaas.no.ORCID 0000-0002-0857-0628
Oslo University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesPatients with classic locked-in syndrome (LIS), typically caused by ventral pontine stroke, present with quadriplegia, mutism, intact consciousness, and communication skills limited to vertical gazing and/or blinking. Clinical presentations and definitions of

methodsA national cohort of patients with vascular LIS who remained in the LIS state for at least 6 weeks according to a functional definition of

resultsThe sample included 51 patients (median age: 55.7 years, 36 male individuals), 43 of whom had follow-up data. Ischemic stroke was the most common etiology (n = 35). Twenty-three patients had emerged from the LIS state, mostly within 2 years after onset. All but 1 patient achieved some motor improvement, whereas only 3 achieved full motor recovery, and 88% had a persistently high level of dependence. The 3-year survival rate was 87%. Five patients had an isolated pontine lesion, whereas 80% showed various lesions outside the brain stem. Patients who emerged from the LIS state had a significantly lower prevalence of lesions outside the brain stem than patients who remained in the LIS state did. DISCUSSION: Investigating an unselected population-based sample of patients with vascular LIS offers important insights into the functional diversity of LIS. Although most patients remained severely disabled, even small improvements in function can substantially increase the potential for activity and participation. Additional lesions outside the brain stem seem to be common in long-lasting LIS and might be prognostic for remaining in the LIS state.

Indexed as

Locked-In SyndromeCommunicationConsciousnessDemographyHumansMaleMiddle AgedQuadriplegia

Identifiers

PMID37442623
PMCPMC10491452
OpenAlexW4384154590

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.