Evidence map›Paper›PMID 37442462›Full record

ArticleThe Science of the total environment2023

Detection of the clinically persistent, pathogenic yeast spp. Candida auris from hospital and municipal wastewater in Miami-Dade County, Florida.

Kristina Babler, Mark Sharkey, Sebastian Arenas, Ayaaz Amirali, Cynthia Beaver, Samuel Comerford, Kenneth Goodman, George Grills, Michelle Holung, Erin Kobetz and 11 more

Open access · greenAbstract read
In one paragraph

Article in The Science of the total environment, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 1 country.

Kristina BablerDepartment of Chemical, Environmental, and Materials Engineering, University of Miami, Coral Gables, FL 33146, USA.
Mark SharkeyDepartment of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Sebastian ArenasDepartment of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Ayaaz AmiraliDepartment of Chemical, Environmental, and Materials Engineering, University of Miami, Coral Gables, FL 33146, USA.
Cynthia BeaverSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Samuel ComerfordDepartment of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Kenneth GoodmanDepartment of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Institute for Data Science & Computing, University of Miami, Coral Gables, FL, USA.
George GrillsSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Michelle HolungDepartment of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Erin KobetzDepartment of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Jennifer LaineEnvironmental Health and Safety, University of Miami, Miami, FL 33136, USA.
Walter LamarDivision of Occupational Health, Safety & Compliance, University of Miami Health System, Miami, FL 33136, USA.
Christopher MasonDepartment of Physiology and Biophysics, Weill Cornell Medical College, New York City, NY 10021, USA; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA; The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY 10021, USA.
Darryl ProntyDepartment of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Brian RedingEnvironmental Health and Safety, University of Miami, Miami, FL 33136, USA.
Stephan SchürerSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Department of Molecular & Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Institute for Data Science & Computing, University of Miami, Coral Gables, FL, USA.
Natasha Schaefer SolleDepartment of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Mario StevensonDepartment of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Dusica VidovićDepartment of Molecular & Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Helena Solo-GabrieleDepartment of Chemical, Environmental, and Materials Engineering, University of Miami, Coral Gables, FL 33146, USA.
Bhavarth ShuklaDepartment of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA. Electronic address: bxs729@miami.edu.
University of Miami · USSylvester Comprehensive Cancer Center · USUniversity of Miami Health System · USWeill Cornell Medicine · US

Funding

University of Miami Developmental Center for AIDS Research (D-CFAR)P30AI073961 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ALLAN E RODRIGUEZ · 2007 to 2026
$33.8M
Supplement for MINI point-of-use deviceU01DA053941 · NIDA · UNIVERSITY OF MIAMI CORAL GABLES · PI MASON, CHRISTOPHER EDWARD, SCHURER, STEPHAN C · 2021 to 2022
$5.2M
NIAID NIH HHS P30 AI073961NIDA NIH HHS U01 DA053941
6 · The paper itself

Abstract

The use of wastewater-based surveillance (WBS) for detecting pathogens within communities has been growing since the beginning of the COVID-19 pandemic with early efforts investigating severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) RNA in wastewater. Recent efforts have shed light on the utilization of WBS for alternative targets, such as fungal pathogens, like Candida auris, in efforts to expand the technology to assess non-viral targets. The objective of this study was to extend workflows developed for SARS-CoV-2 quantification to evaluate whether C. auris can be recovered from wastewater, inclusive of effluent from a wastewater treatment plant (WWTP) and from a hospital with known numbers of patients colonized with C. auris. Measurements of C. auris in wastewater focused on culture-based methods and quantitative PCR (qPCR). Results showed that C. auris can be cultured from wastewater and that levels detected by qPCR were higher in the hospital wastewater compared to the wastewater from the WWTP, suggesting either dilution or degradation of this pathogenic yeast at downstream collection points. The results from this study illustrate that WBS can extend beyond SARS-CoV-2 monitoring to evaluate additional non-viral pathogenic targets and demonstrates that C. auris isolated from wastewater is competent to replicate in vitro using fungal-specific culture media.

Indexed as

COVID-19Candida aurisFloridaHumansPandemicsSaccharomyces cerevisiaeSARS-CoV-2WastewaterWastewaterCandidaC. aurisSARS-CoV-2WastewaterWastewater-based surveillanceWBS

Identifiers

PMID37442462
PMCPMC10543605
OpenAlexW4384038211

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.