ArticleJournal of the American Chemical Society2023
Bioconjugation of a Near-Infrared DNA-Stabilized Silver Nanocluster to Peptides and Human Insulin by Copper-Free Click Chemistry.
Article in Journal of the American Chemical Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 48 citations in OpenAlex.
- Dual Cluster-Surface Click Chemistries on Silver Nanoclusters.Small science · 2026Article
- Unlocking Two-Photon Chiral Signatures in DNA-Stabilized Silver Nanoclusters: Two-Photon Circular Dichroism and Circularly Polarized Luminescence.Advanced optical materials · 2026Article
- Xeno-nucleic acids support formation of Ag(I)-mediated duplexes and silver nanoclusters.Nucleic acids research · 2026Article
- Functionalizing metal nanoclusters in water: Synthesis, interfacing, and emerging applications.PNAS nexus · 2026Article
- Bionanoconjugates in Neurodegeneration: Peptide-Nanoparticle Alliances for Next-Generation Therapies.Pharmaceutical research · 2025Review
- Correlating the Crystal Structure and Optical Response of DNA-Stabilized AgThe journal of physical chemistry. C, Nanomaterials and interfaces · 2025Article
- Silver Binding Dichotomy for 7-Deazaadenine/Thymine: Preference for Watson-Crick Pairing over Homobase Interactions in DNA.Inorganic chemistry · 2025Article
- Design Principles Of Inorganic-Protein Hybrid Materials for Biomedicine.Exploration (Beijing, China) · 2025Review
- Structure of a DNA-Stabilized AgAngewandte Chemie (International ed. in English) · 2025Article
- Article
- The role of dysregulated copper metabolism in diabetes and its complications: a review.Frontiers in endocrinology · 2025Review
- On the Chemical Stability of DNA-Stabilized Silver Nanoclusters.ACS omega · 2024Article
- An Atom-Precise Understanding of DNA-Stabilized Silver Nanoclusters.Accounts of chemical research · 2024Review
- Fluorescence Screening of DNA-AgNCs with Pulsed White Light Excitation.Nano letters · 2024Article
- Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA-stabilized silver nanoclusters (DNA-AgNCs) are biocompatible emitters with intriguing properties. However, they have not been extensively used for bioimaging applications due to the lack of structural information and hence predictable conjugation strategies. Here, a copper-free click chemistry method for linking a well-characterized DNA-AgNC to molecules of interest is presented. Three different peptides and a small protein, human insulin, were tested as labeling targets. The conjugation to the target compounds was verified by MS, HPLC, and time-resolved anisotropy measurements. Moreover, the spectroscopic properties of DNA-AgNCs were found to be unaffected by the linking reactions. For DNA-AgNC-conjugated human insulin, fluorescence imaging studies were performed on Chinese hamster ovary (CHO) cells overexpressing human insulin receptor B (hIR-B). The specific staining of the CHO cell membranes demonstrates that DNA-AgNCs are great candidates for bioimaging applications, and the proposed linking strategy is easy to implement when the DNA-AgNC structure is known.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.