Evidence map›Paper›PMID 37441763›Full record

ArticleThe Journal of organic chemistry2023

Practical Synthesis of Terminal Vinyl Fluorides.

Ivan Volchkov, Brent V Powell, Olga V Zatolochnaya, Joyce C Leung, Scott Pennino, Lifen Wu, Nina C Gonnella, Bangaru Bhaskararao, Marisa C Kozlowski, Jonathan T Reeves

Abstract read
In one paragraph

Article in The Journal of organic chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ivan VolchkovDepartments of Chemical Development and Material and Analytical Sciences, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut 06877, United States.
Brent V PowellDepartments of Chemical Development and Material and Analytical Sciences, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut 06877, United States.
Olga V ZatolochnayaDepartments of Chemical Development and Material and Analytical Sciences, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut 06877, United States.
Joyce C LeungDepartments of Chemical Development and Material and Analytical Sciences, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut 06877, United States.ORCID 0000-0003-2246-1599
Scott PenninoDepartments of Chemical Development and Material and Analytical Sciences, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut 06877, United States.
Lifen WuDepartments of Chemical Development and Material and Analytical Sciences, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut 06877, United States.
Nina C GonnellaDepartments of Chemical Development and Material and Analytical Sciences, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut 06877, United States.ORCID 0000-0001-8944-7180
Bangaru BhaskararaoDepartment of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0003-1618-0707
Marisa C KozlowskiDepartment of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0002-4225-7125
Jonathan T ReevesDepartments of Chemical Development and Material and Analytical Sciences, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut 06877, United States.ORCID 0000-0002-3051-3304

Funding

Computation and Development of New, Enabling Synthetic MethodsR35GM131902 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Marisa C Kozlowski · 2019 to 2026
$4.5M
NIGMS NIH HHS R35 GM131902
6 · The paper itself

Abstract

The synthesis of di- and trisubstituted vinyl fluorides with high isomeric purity remains a challenge for organic synthesis. While many methods exist to access these compounds, the separation of the desired isomer from the minor isomer and/or starting materials often is difficult. Herein, we report a practical method to access di- and trisubstituted vinyl fluorides via a selective Horner-Wadsworth-Emmons olefination/hydrolysis, which provides crystalline 2-fluoroacrylic acids in high (>98%)

Identifiers

PMID37441763
PMCPMC10530197

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.