Evidence map›Paper›PMID 37441691›Full record

SynthesisFrontiers in medicine2023

Efficacy and safety of platelet-rich plasma injections for the treatment of osteoarthritis: a systematic review and meta-analysis of randomized controlled trials.

Yongqing Xiong, Cheng Gong, Xumiao Peng, Xianlei Liu, Xinda Su, Xi Tao, Ying Li, Youliang Wen, Wei Li

2 registry-linked trialsOpen access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 63 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 4 pooled it
25.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06543368 nacompletednot on this mapstarted 2024, after this paper: background citation

Low-Cost Platelet-Rich Plasma Injection for the Management of Hemarthropathy

TypeinterventionalSponsorUniversity of UtahRan2024 to 2025Enrolled14ConditionsHemarthrosis, HemophiliaArmsIntra articular PRP Injection
NCT07231471 narecruitingnot on this mapstarted 2025, after this paper: background citation

Platelet Rich Plasma for Musculoskeletal Conditions

TypeinterventionalSponsorUniversity of UtahRan2025 to 2035Enrolled10,000ConditionsOsteoarthritis (OA), Osteoarthritis (OA) of the Knee, Osteoarthritis (OA) of the Hip, Osteoarthritis (OA) of the ShoulderArmsPlatelet Rich Plasma Injection, Platelet Rich Plasma Preparation
3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 4 syntheses or guidelines pooled it, 85 citations in OpenAlex.

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  12. Cross-Linked Versus Linear Hyaluronic Acid for Cartilage Repair in Rat Post-Traumatic Osteoarthritis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yongqing Xiong *Gannan Medical University, Ganzhou, Jiangxi, China.
Cheng Gong *Gannan Medical University, Ganzhou, Jiangxi, China.
Xumiao Peng *Gannan Medical University, Ganzhou, Jiangxi, China.
Xianlei LiuGannan Medical University, Ganzhou, Jiangxi, China.
Xinda SuGannan Medical University, Ganzhou, Jiangxi, China.
Xi TaoGannan Medical University, Ganzhou, Jiangxi, China.
Ying LiGannan Medical University, Ganzhou, Jiangxi, China.
Youliang WenGannan Medical University, Ganzhou, Jiangxi, China.
Wei LiGannan Medical University, Ganzhou, Jiangxi, China.
Gannan Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In recent years, platelet-rich plasma (PRP) injections for osteoarthritis (OA) have been widely promoted in clinical practice, but their effectiveness is controversial. Therefore, we conducted a meta-analysis of relevant randomized controlled trials (RCTs) to determine the efficacy and safety of PRP injections for the treatment of OA. Methods: We searched databases including Embase, Web of Science, Medline, PubMed, and the Cochrane Library for relevant studies. Two researchers (YQX and CG) performed literature screening, baseline data extraction, literature quality assessment, and heterogeneity analysis of RCTs from the retrieved studies. Based on the magnitude of heterogeneity Results: We included 24 RCTs comprising 1344 patients with OA who met the inclusion criteria, with the main types of morbidity being knee osteoarthritis (KOA), hip osteoarthritis (HOA), ankle osteoarthritis (AOA), and temporomandibular joint osteoarthritis (TMJOA). Our results indicate that PRP injections were effective in improving Visual Analog Scale (VAS) pain scores in patients with KOA, HOA, and AOA compared to controls (AOA, MD = -1.15, CI = 95% [-1.74, -0.56], Conclusion: PRP injection therapy can safely and effectively improve functional activity in patients with OA and produce positive analgesic effects in patients with KOA, TMJOA, and AOA. However, PRP injection therapy did not significantly reduce pain symptoms in patients with HOA. In addition, the analgesic effect of LP-PRP was greater than that of LR-PRP. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42022362066.

Indexed as

meta-analysisosteoarthritisplatelet-rich plasmarandomized controlled trialssystematic review

Identifiers

PMID37441691
PMCPMC10333515
OpenAlexW4382248683

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.