Evidence map›Paper›PMID 37441616›Full record

ArticlePNAS nexus2023

Gene-environment interactions and the case of body mass index and obesity: How much do they matter?

Yiyue Huangfu, Alberto Palloni, Hiram Beltrán-Sánchez, Mary C McEniry

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PNAS nexus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Approach to Obesity Treatment in Primary Care: A Review.JAMA internal medicine · 2024 · on this map
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yiyue HuangfuCenter for Demography and Health of Aging, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID https://orcid.org/0000-0002-4221-6294
Alberto PalloniCenter for Demography and Health of Aging, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID https://orcid.org/0000-0002-2263-2207
Hiram Beltrán-SánchezFielding School of Public Health and California Center for Population Research, UCLA, CA 90095, USA.ORCID https://orcid.org/0000-0002-8334-6191
Mary C McEniryCenter for Demography and Health of Aging, University of Wisconsin-Madison, Madison, WI 53706, USA.

Funding

Scientific and Technical CoreP2CHD041022 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Martha Jane Bailey · 2016 to 2026
$6.9M
NICHD NIH HHS P2C HD041022
6 · The paper itself

Abstract

We investigate the demographic and population health implications of gene-environment interactions (GxE) in the case of body mass index (BMI) and obesity. We seek to answer two questions: (a) what is the first-order impact of GxE effects on BMI and probability of obesity, e.g. the direct causal effect of G in different E's? and (b) how large is the impact of GxE effects

Indexed as

gene–environment interactionsobesitySocial Sciencestype 2 diabetes

Identifiers

PMID37441616
PMCPMC10335730

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.