Evidence map›Paper›PMID 37441614›Full record

ArticlePNAS nexus2023

A subcellular biochemical model for T6SS dynamics reveals winning competitive strategies.

Yuexia Luna Lin, Stephanie N Smith, Eva Kanso, Alecia N Septer, Chris H Rycroft

Open access · goldAbstract read
In one paragraph

Article in PNAS nexus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Decoding resistance in the age of T6SS warfare.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Lighting the way: how theJournal of bacteriology · 2024
    Review
  7. Article
  8. ThebioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Yuexia Luna LinFlexible Structures Laboratory, Ecole Polytechnique Fédérale de Lausanne (EPFL), Rte Cantonale, Lausanne CH-1015, Switzerland.ORCID https://orcid.org/0000-0003-4073-7974
Stephanie N SmithDepartment of Earth, Marine, and Environmental Sciences, University of North Carolina, 121 South Road, Chapel Hill, NC 27599, USA.ORCID https://orcid.org/0000-0002-3709-4464
Eva KansoDepartment of Aerospace and Mechanical Engineering, University of Southern California, 3650 McClintock Ave, Los Angeles, CA 90089, USA.ORCID https://orcid.org/0000-0003-0336-585X
Alecia N SepterDepartment of Earth, Marine, and Environmental Sciences, University of North Carolina, 121 South Road, Chapel Hill, NC 27599, USA.ORCID https://orcid.org/0000-0002-9309-2930
Chris H RycroftJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, 29 Oxford Street, Cambridge, MA 02138, USA.ORCID https://orcid.org/0000-0003-4677-6990
University of North Carolina at Chapel Hill · USHarvard University · USUniversity of Southern California · USUniversity of Wisconsin–Madison · US

Funding

Genetic determinants of interbacterial competition during host colonizationR35GM137886 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Alecia Septer · 2020 to 2026
$2.6M
Quantitative analysis of mucociliary clearance in airway ciliopathiesR01HL153622 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KANSO, EVA, RYAN, AMY LEANNE · 2021 to 2024
$1.9M
NHLBI NIH HHS R01 HL153622NIGMS NIH HHS R35 GM137886
6 · The paper itself

Abstract

The type VI secretion system (T6SS) is a broadly distributed interbacterial weapon that can be used to eliminate competing bacterial populations. Although unarmed target populations are typically used to study T6SS function in vitro, bacteria most likely encounter other T6SS-armed competitors in nature. However, the connection between subcellular details of the T6SS and the outcomes of such mutually lethal battles is not well understood. Here, we incorporate biological data derived from natural competitors of

Indexed as

agent-based modelAliivibrio fischeri type VI secretion systemcompetitionsheath number distributionviscosity activation

Identifiers

PMID37441614
PMCPMC10335733
OpenAlexW4380537981

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.