Evidence map›Paper›PMID 37441266›Full record

ArticleCancer research communications2023

The African-centric P47S Variant of

David C Stieg, Joshua L D Parris, Tyler Hong Loong Yang, Gauri Mirji, Sarah Kim Reiser, Nivitha Murali, Madison Werts, Thibaut Barnoud, David Y Lu, Rahul Shinde and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cancer research communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

David C StiegProgram in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, Pennsylvania.ORCID 0000-0003-2746-3315
Joshua L D ParrisProgram in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, Pennsylvania.ORCID 0000-0003-2174-823X
Tyler Hong Loong YangProgram in Immunology, Microenvironment, and Metastasis, The Wistar Institute, Philadelphia, Pennsylvania.ORCID 0009-0009-2019-4838
Gauri MirjiProgram in Immunology, Microenvironment, and Metastasis, The Wistar Institute, Philadelphia, Pennsylvania.ORCID 0000-0001-6439-8204
Sarah Kim ReiserProgram in Immunology, Microenvironment, and Metastasis, The Wistar Institute, Philadelphia, Pennsylvania.ORCID 0009-0009-9061-5052
Nivitha MuraliProgram in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, Pennsylvania.ORCID 0009-0002-0218-5080
Madison WertsProgram in Immunology, Microenvironment, and Metastasis, The Wistar Institute, Philadelphia, Pennsylvania.ORCID 0009-0007-2634-5663
Thibaut BarnoudDepartment of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina.ORCID 0000-0001-5588-6281
David Y LuProgram in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, Pennsylvania.ORCID 0000-0001-9932-4336
Rahul ShindeProgram in Immunology, Microenvironment, and Metastasis, The Wistar Institute, Philadelphia, Pennsylvania.ORCID 0000-0001-8767-5032
Maureen E MurphyProgram in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, Pennsylvania.ORCID 0000-0001-7644-7296
Daniel T ClaiborneProgram in Immunology, Microenvironment, and Metastasis, The Wistar Institute, Philadelphia, Pennsylvania.ORCID 0000-0002-2091-1456
The Wistar Institute · USMedical University of South Carolina · US

Funding

Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Nan Zhang · 1985 to 2026
$75.9M
TRAINING PROGRAM IN BASIC CANCER RESEARCHT32CA009171 · NCI · WISTAR INSTITUTE · PI Alessandro Gardini · 1985 to 2026
$15.3M
Functional Analysis of p53 Polymorphic Variants - Diversity SupplementR01CA102184 · NCI · WISTAR INSTITUTE · PI Maureen E. Murphy · 2005 to 2026
$7.4M
Role of the p53 P47S mutation in influencing prevalence and immune response to H. pyloriR01DK124385 · NIDDK · WISTAR INSTITUTE · PI CLAIBORNE, DANIEL THOMAS · 2021 to 2025
$3.0M
The impact of coding region variants on mutant p53 biologyR01CA238611 · NCI · WISTAR INSTITUTE · PI MURPHY, MAUREEN E. · 2020 to 2024
$2.2M
Genetics of Tumor Suppression by p53R00CA241367 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BARNOUD, THIBAUT · 2022 to 2024
$747k
The role of gut microbe-derived choline metabolites in driving the pro-inflammatory macrophage phenotype and restricting pancreatic cancerR21CA259240 · NCI · WISTAR INSTITUTE · PI SHINDE, RAHUL SURESH · 2021 to 2022
$477k
Overcoming the hurdles to successful CAR T cell therapy for a functional HIV cureK22AI150373 · NIAID · WISTAR INSTITUTE · PI CLAIBORNE, DANIEL THOMAS · 2021 to 2022
$270k
NCI NIH HHS P30 CA010815NCI NIH HHS R00 CA241367NCI NIH HHS R01 CA102184NCI NIH HHS R01 CA238611NCI NIH HHS R21 CA259240NCI NIH HHS T32 CA009171NIAID NIH HHS K22 AI150373NIDDK NIH HHS R01 DK124385
6 · The paper itself

Abstract

The tumor suppressor Significance: Findings presented here show that the P47S variant of

Indexed as

Li-Fraumeni SyndromeTumor Suppressor Protein p53AnimalsGenes, p53Germ-Line MutationHumansImmune Checkpoint InhibitorsMiceTumor MicroenvironmentImmune Checkpoint InhibitorsTP53 protein, humanTumor Suppressor Protein p53

Identifiers

PMID37441266
PMCPMC10335007
OpenAlexW4381190310

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.