Evidence map›Paper›PMID 37441134›Full record

ArticleMaterials today. Bio2023

Fluorescent nanodiamond labels: Size and concentration matters for sperm cell viability.

Claudia Reyes San-Martin, Yue Zhang, Thamir Hamoh, Lotte Berendse, Carline Klijn, Runrun Li, Alina Sigaeva, Jakub Kawałko, Hui Ting Li, Jian Tehrani and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Claudia Reyes San-MartinGroningen University, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AW, Groningen, Netherlands.
Yue ZhangGroningen University, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AW, Groningen, Netherlands.
Thamir HamohGroningen University, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AW, Groningen, Netherlands.
Lotte BerendseGroningen University, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AW, Groningen, Netherlands.
Carline KlijnGroningen University, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AW, Groningen, Netherlands.
Runrun LiGroningen University, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AW, Groningen, Netherlands.
Alina SigaevaGroningen University, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AW, Groningen, Netherlands.
Jakub KawałkoAGH University of Science and Technology, Academic Centre for Materials and Nanotechnology, Al. A. Mickiewicza 30, 30-059, Krakow, Poland.
Hui Ting LiGroningen University, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AW, Groningen, Netherlands.
Jian TehraniGroningen University, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AW, Groningen, Netherlands.
Aldona MzykGroningen University, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AW, Groningen, Netherlands.
Romana SchirhaglGroningen University, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AW, Groningen, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanodiamonds are increasingly popular in biomedical applications, including optical labelling, drug delivery and nanoscale sensing. Potential new applications are in studying infertility or labelling sperm cells. However, for these applications, it is necessary that nanodiamonds are inert and do not alter sperm properties. In this article, we assessed the biocompatibility of nanodiamonds in detail. We investigated different sizes and concentrations of nanodiamonds and sperm preparation methods. We evaluated if the metabolic activity, membrane integrity, morphology and formation of reactive oxygen species were altered. These parameters were tested for sperm cells in their uncapacitated and capacitated states. Unfortunately, FNDs are not universally biocompatible. Generally, cells in the capacitated state are more prone to stress. Additionally, larger particles and lower concentrations are tolerated better than smaller and higher concentrated particles.

Indexed as

BiocompatibilityNanodiamondsNV centersSperm cells

Identifiers

PMID37441134
PMCPMC10333662

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.