Evidence map›Paper›PMID 37441063›Full record

ReviewFrontiers in immunology2023

Dissecting the regulatory network of transcription factors in T cell phenotype/functioning during GVHD and GVT.

Rebecca Harris, Mobin Karimi

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Deep insight into cytokine storm: from pathogenesis to treatment.Signal transduction and targeted therapy · 2025
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Rebecca HarrisDepartment of Microbiology and Immunology, State University of New York (SUNY) Upstate Medical University, Syracuse, NY, United States.
Mobin KarimiDepartment of Microbiology and Immunology, State University of New York (SUNY) Upstate Medical University, Syracuse, NY, United States.
SUNY Upstate Medical University · US

Funding

Novel strategies to separate GVHD from GVTK22AI130182 · NIAID · UPSTATE MEDICAL UNIVERSITY · PI KARIMI, MOBIN · 2017 to 2018
$266k
NIAID NIH HHS K22 AI130182
6 · The paper itself

Abstract

Transcription factors play a major role in regulation and orchestration of immune responses. The immunological context of the response can alter the regulatory networks required for proper functioning. While these networks have been well-studied in canonical immune contexts like infection, the transcription factor landscape during alloactivation remains unclear. This review addresses how transcription factors contribute to the functioning of mature alloactivated T cells. This review will also examine how these factors form a regulatory network to control alloresponses, with a focus specifically on those factors expressed by and controlling activity of T cells of the various subsets involved in graft-versus-host disease (GVHD) and graft-versus-tumor (GVT) responses.

Indexed as

Graft vs Host DiseaseNeoplasmsHumansT-LymphocytesTranscription FactorsTransplantation, HomologousTranscription FactorsallotransplantationGVHDGVLregulatory networkstranscription factors

Identifiers

PMID37441063
PMCPMC10333690
OpenAlexW4382241996

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.