Evidence map›Paper›PMID 37440761›Full record

ArticleEuropean heart journal. Cardiovascular Imaging2023

Neuroticism personality traits are linked to adverse cardiovascular phenotypes in the UK Biobank.

Adil Mahmood, Judit Simon, Jackie Cooper, Theodore Murphy, Celeste McCracken, Juan Quiroz, Liliana Laranjo, Nay Aung, Aaron Mark Lee, Mohammed Y Khanji and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal. Cardiovascular Imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Stress-related genetic factors modify the effect of socioeconomic status on cardiovascular risk.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Adil MahmoodWilliam Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.ORCID 0000-0001-9834-6920
Judit SimonMTA-SE Cardiovascular Imaging Research Group, Department of Radiology, Medical Imaging Centre, Semmelweis University, Budapest, Hungary.ORCID 0000-0001-8063-3462
Jackie CooperWilliam Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Theodore MurphyDepartment of Cardiology and Cardiovascular Imaging, Beacon Hospital, Dublin, Ireland.
Celeste McCrackenWilliam Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.ORCID 0000-0003-1285-2393
Juan QuirozCentre for Big Data Research in Health (CBDRH), The University of New South Wales (UNSW), Sydney, Australia.
Liliana LaranjoFaculty of Medicine and Health, Westmead Applied Research Centre (WARC), University of Sydney, Australia.ORCID 0000-0003-1020-3402
Nay AungWilliam Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.ORCID 0000-0001-5095-1611
Aaron Mark LeeWilliam Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Mohammed Y KhanjiWilliam Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Stefan NeubauerDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford OX3 9DU, UK.ORCID 0000-0001-9017-5645
Zahra Raisi-EstabraghWilliam Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Pal Maurovich-HorvatMTA-SE Cardiovascular Imaging Research Group, Department of Radiology, Medical Imaging Centre, Semmelweis University, Budapest, Hungary.
Steffen E PetersenWilliam Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Queen Mary University of London · GBSt Bartholomew's Hospital · GBSemmelweis University · HUNational Institute for Health Research · GBThe University of Sydney · AUUNSW Sydney · AU

Funding

Academic Clinical Lectureship G-002346AI4VBHAI4VBH consortiumBHFEarly Diagnosis and Precision MedicineEPSRC programmeEuropean Union's Horizon 2020 research and innovation programme 825903Industrial Strategy Challenge FundInnovate UKIrish Cardiac SocietyLondon Medical ImagingNHSNIHR Barts Biomedical Research CentreNIHR Integrated Academic Training programmeNIHR Oxford Biomedical Research CentreOxford BHF Centre of Research ExcellenceUK Biobank #2964UKRI
6 · The paper itself

Abstract

aimsTo evaluate the relationship between neuroticism personality traits and cardiovascular magnetic resonance (CMR) measures of cardiac morphology and function, considering potential differential associations in men and women. METHODS AND

resultsThe analysis includes 36 309 UK Biobank participants (average age = 63.9 ± 7.7 years; 47.8% men) with CMR available and neuroticism score assessed by the 12-item Eysenck Personality Questionnaire-Revised Short Form. CMR scans were performed on 1.5 Tesla scanners (MAGNETOM Aera, Siemens Healthcare, Erlangen, Germany) according to pre-defined protocols and analysed using automated pipelines. We considered measures of left ventricular (LV) and right ventricular (RV) structure and function, and indicators of arterial compliance. Multivariable linear regression was used to estimate association of neuroticism score with individual CMR metrics, with adjustment for age, sex, obesity, deprivation, smoking, diabetes, hypertension, hypercholesterolaemia, alcohol use, exercise, and education. Higher neuroticism scores were associated with smaller LV and RV end-diastolic volumes, lower LV mass, greater concentricity (higher LV mass to volume ratio), and higher native T1. Greater neuroticism was also linked to poorer LV and RV function (lower stroke volumes) and greater arterial stiffness. In sex-stratified analyses, the relationships between neuroticism and LV stroke volume, concentricity, and arterial stiffness were attenuated in women. In men, association (with exception of native T1) remained robust.

conclusionGreater tendency towards neuroticism personality traits is linked to smaller, poorer functioning ventricles with lower LV mass, higher myocardial fibrosis, and higher arterial stiffness. These relationships are independent of traditional vascular risk factors and are more robust in men than women.

Indexed as

Biological Specimen BanksVentricular Function, LeftAgedFemaleHeart VentriclesHumansMagnetic Resonance Imaging, CineMaleMiddle AgedNeuroticismPersonalityStroke VolumeUnited Kingdomcardiac functioncardiac morphologycardiovascular magnetic resonancecardiovascular remodellingmental healthneuroticism

Identifiers

PMID37440761
PMCPMC10610755
OpenAlexW4384277440

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.