ArticleScience (New York, N.Y.)2023
Recruited macrophages elicit atrial fibrillation.
Open access · greenAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 157 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
157citing papers in PubMed, 2 pooled it
31.7field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
157 citing papers in PubMed, 2 syntheses or guidelines pooled it, 193 citations in OpenAlex.
- Beyond the beats: a systematic review of the underlying inflammatory pathways between atrial fibrillation and cognitive decline.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Pooled it
- Bioinformatics Analysis Reveals HIST1H2BH as a Novel Diagnostic Biomarker for Atrial Fibrillation-Related Cardiogenic Thromboembolic Stroke.Molecular biotechnology · 2025Pooled it
- Monocyte Activation Drives Atrial Fibrillation in Hypertension.Cardiovascular drugs and therapy · 2026Article
- Roles of inflammation and metabolic dysfunction in cardiovascular diseases: molecular mechanisms and therapeutic targets.Molecular biomedicine · 2026Review
- Multi-omic analysis of jaw-bone periosteum identifies the role of macrophage-derived SPP1 in CtskBone research · 2026Article
- Single nucleus transcriptomics reveals ITGA8-driven fibroblast remodeling in rheumatic valvular atrial fibrillation.iScience · 2026Article
- Mechanisms of regeneration and maladaptive repair in acute kidney injury.Nature reviews. Nephrology · 2026Review
- Understanding the Diseased Atria.Physiology (Bethesda, Md.) · 2026Review
- Dynamic cellular programs of human cardiac allograft rejection revealed by spatial transcriptomics.Nature cardiovascular research · 2026Article
- Single-Cell Transcriptomics and Mendelian Randomization Analysis Reveal Key Genes in Atrial Fibrillation.Journal of cardiovascular electrophysiology · 2026Article
- Understanding atrial failure: from diagnosis to clinical implications.Nature reviews. Cardiology · 2026Review
- The Defect of iNKT Cells Mediates Mitochondrial Dysfunction Through IL-6/STAT3 Signaling to Induce Atrial Inflammation and Fibrosis to Aggravate Postoperative Atrial Fibrillation.Physiological research · 2026Article
- Gut microbiota-activated PLCγ2 monocytes drive atrial fibrillation.Nature communications · 2026Article
- Adipose-Myocardial Border in Atrial Fibrillation.Circulation research · 2026Article
- Cardiac immunity and heart repair: Mechanism, challenge, and future direction.Chinese medical journal · 2026Review
- The Immune System as a Proarrhythmic Mediator: A Novel Paradigm for the Development of New Antiarrhythmic Therapy.The Canadian journal of cardiology · 2026Review
- Targeting SPP1 requires moving beyond ligand blockade.Cellular & molecular immunology · 2026Article
- Multiomics Insights Into the Role of Spondin-1 in the Pathogenesis and Prognosis of Atrial Fibrillation.Journal of the American Heart Association · 2026Article
- Epicardial Contributions to Fibro-Inflammatory Signaling in a Pkp2-Deficient Arrhythmogenic Cardiomyopathy Model.Circulation. Heart failure · 2026Article
- The clinical pathophysiology of atrial fibrillation: outstanding questions from bedside to bench and back.Physiological reviews · 2026Review
97 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
38 authors at 10 institutions in 4 countries.
Maarten Hulsmans *Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-1009-658X
Maximilian J Schloss *Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0009-0007-4979-690X
I-Hsiu Lee *Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-7200-7867
Aneesh BapatCardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-1996-522X
Yoshiko IwamotoCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Claudio VinegoniCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-9818-3639
Alexandre PaccaletCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-6331-562X
Masahiro YamazoeCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Jana GruneCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-6209-7416
Steffen PabelCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Noor MominCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-3145-6089
Hana SeungCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0009-0004-7754-787X
Nina KumowskiCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-3355-9102
Fadi E PulousCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-0794-8078
Daniel KellerDepartment of Thoracic and Cardiovascular Surgery, University Hospital Wuerzburg, Wuerzburg, Germany.ORCID 0009-0005-5776-3310
Constanze BeningDepartment of Thoracic and Cardiovascular Surgery, University Hospital Wuerzburg, Wuerzburg, Germany.
Ursula GreenDepartment of Pathology, Center for Integrated Diagnostics, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-5842-280X
Jochen K LennerzDepartment of Pathology, Center for Integrated Diagnostics, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-2434-4978
Richard N MitchellDepartment of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-0329-7618
Andrew LewisRadcliffe Department of Medicine, NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.ORCID 0000-0002-3714-6711
Barbara CasadeiRadcliffe Department of Medicine, NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.ORCID 0000-0002-6801-1617
Oriol Iborra-EgeaInstitut del Cor Germans Trias i Pujol, CIBERCV, Badalona, Barcelona, Spain.ORCID 0000-0002-7280-859X
Antoni Bayes-GenisInstitut del Cor Germans Trias i Pujol, CIBERCV, Badalona, Barcelona, Spain.ORCID 0000-0002-3044-197X
Samuel SossallaDepartment of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany.
Chin Siang OngDivision of Cardiac Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-4521-0971
Richard N PiersonDivision of Cardiac Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-3764-4590
Jon C AsterDepartment of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
David RohdeCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-3785-9375
Gregory R WojtkiewiczCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-3148-8411
Ralph WeisslederCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-0828-4143
Filip K SwirskiCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-3163-9152
George TellidesDepartment of Surgery, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-7042-8190
George TolisDepartment of Cardiac Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Serguei MelnitchoukDivision of Cardiac Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0009-0009-2983-3472
David J MilanLeducq Foundation, Boston, MA, USA.
Patrick T EllinorCardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-2067-0533
Kamila Naxerova *Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-7744-5110
Matthias Nahrendorf *Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-4021-1887
Harvard University · USBrigham and Women's Hospital · USBritish Heart Foundation · GBInstitut d'Investigació en Ciències de la Salut Germans Trias i Pujol · ESUniversitätsklinikum Würzburg · DEBoston Foundation · USBroad Institute · USGerman Centre for Cardiovascular Research · DEIcahn School of Medicine at Mount Sinai · USYale University · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6MIDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6MPROJECT 4: Somatic evolution of the hematopoietic system in cardiovascular diseaseP01HL142494 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Matthias Nahrendorf · 2019 to 2026
$19.5MTRAINING PROGRAM IN CARDIOVASCULAR RESEARCHT32HL007604 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MARK W FEINBERG · 1985 to 2026
$19.0MImaging organ system interfaces in ischemic heart diseaseR35HL139598 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NAHRENDORF, MATTHIAS · 2018 to 2024
$6.9MGenomics of Cardiac ArrhythmiasR01HL139731 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ELLINOR, PATRICK THOMAS · 2018 to 2022
$3.3MIlluminating the evolutionary history of colorectal cancer metastasis: basic principles and clinical applicationsR37CA225655 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI NAXEROVA, KAMILA · 2018 to 2024
$3.0MCardiac resident macrophages in AV node conductionR01HL149647 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HULSMANS, MAARTEN · 2022 to 2025
$2.9MUsing Electrocardiogram Genetics to Inform Arrhythmia RiskR01HL157635 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ELLINOR, PATRICK THOMAS, MIRSHAHI, TOORAJ · 2022 to 2025
$2.9MMacrophage heterogeneity in atrial remodelingR01HL155097 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HULSMANS, MAARTEN · 2021 to 2025
$2.9MBone Marrow Endothelial VEGFR3 Regulation of Leukocyte Trafficking in Myocardial InfarctionF32HL158040 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI PULOUS, FADI EMAD · 2021 to 2023
$121kBritish Heart Foundation CH/12/3/29609British Heart Foundation PG/2019/34842British Heart Foundation RG/16/12/32451NCATS NIH HHS UL1 TR001863NCI NIH HHS R37 CA225655NHLBI NIH HHS F32 HL158040NHLBI NIH HHS P01 HL142494NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL139731NHLBI NIH HHS R01 HL149647NHLBI NIH HHS R01 HL155097NHLBI NIH HHS R01 HL157635NHLBI NIH HHS R35 HL139598NHLBI NIH HHS T32 HL007604NIDDK NIH HHS P30 DK040561
Abstract
Atrial fibrillation disrupts contraction of the atria, leading to stroke and heart failure. We deciphered how immune and stromal cells contribute to atrial fibrillation. Single-cell transcriptomes from human atria documented inflammatory monocyte and
Indexed as
Atrial FibrillationMacrophagesOsteopontinAnimalsCell MovementGene DeletionHeart AtriaHumansMiceMitral Valve InsufficiencySingle-Cell Gene Expression AnalysisOsteopontinSPP1 protein, humanSpp1 protein, mouse
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