ArticleJournal of the American Chemical Society2023
Asymmetric Catalytic Friedel-Crafts Reactions of Unactivated Arenes.
Article in Journal of the American Chemical Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Catalytic Enantioselective Diels-Alder Reaction of Dienes with Acyclic and α,β- and β,β-Disubstituted Enones.Journal of the American Chemical Society · 2025Article
- Catalytic Asymmetric (Journal of the American Chemical Society · 2025Article
- Manganese-Catalyzed Enantioselective Dearomative Epoxidation of Naphthalenes with Aqueous Hydrogen Peroxide.Angewandte Chemie (International ed. in English) · 2025Article
- Molybdenum-Catalyzed Asymmetric Amination of α-Hydroxy Esters: Synthesis of α-Amino Acids.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Catalytic Asymmetric Cycloaddition of Olefins with In Situ GeneratedJournal of the American Chemical Society · 2024Article
- Highly Acidic Electron-Rich Brønsted Acids Accelerate Asymmetric Pictet-Spengler Reactions by Virtue of Stabilizing Cation-π Interactions.Journal of the American Chemical Society · 2024Article
- Regio- and EnantioselectiveOrganic letters · 2024Article
- Enantioselective organocatalytic strategies to access noncanonical α-amino acids.Chemical science · 2024Review
- Aza-Achmatowicz rearrangement coupled with intermolecular aza-Friedel-Crafts enables total syntheses of uleine and aspidosperma alkaloids.Chemical science · 2024Article
- Tunable C-H functionalization and dearomatization enabled by an organic photocatalyst.Chemical science · 2024Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since its discovery more than a century ago, the Friedel-Crafts reaction has manifested itself as a powerful method for the introduction of carbon substituents to arenes. Despite its potential generality, the scope of the reaction is intrinsically limited by the arene's nucleophilicity, which has previously restrained the applicability of asymmetric variants to activated substrates. To overcome this fundamental limitation, we report herein an asymmetric Friedel-Crafts reaction of unactivated, purely hydrocarbon arenes, alkoxybenzenes, and heteroarenes with
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