SynthesisThe British journal of surgery2023
Prolonged antibiotic prophylaxis after pancreatoduodenectomy: systematic review and meta-analysis.
Synthesis in The British journal of surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07248527 (PAN-ICIS), which is not on this map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
PAN-ICIS: Prospective Observational Study Evaluating the Intensive Care Infection Score for Early Detection of Infectious Complications After Pancreatic Resections
Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Impact of multidrug-resistant microorganisms in bile on postoperative outcomes and long-term survival in patients with periampullary malignancies.Updates in surgery · 2026Article
- Impact of preoperative internal versus external biliary drainage on surgical and oncological outcomes after pancreaticoduodenectomy: a systematic review and meta-analysis.International journal of surgery (London, England) · 2026Article
- Article
- Should Preoperative Biliary Decontamination Be Considered to Minimize Morbidity and Mortality Following Pancreatoduodenectomy?Antibiotics (Basel, Switzerland) · 2026Article
- Prolonged Prophylactic Antibiotics Based on Preoperative Bile Culture Reduce Surgical Site Infections After Pancreaticoduodenectomy Following Preoperative Biliary Drainage: A Propensity-Matched Analysis.Annals of gastroenterological surgery · 2026Article
- Extended antibiotic prophylaxis beyond 24 h after pancreatic surgery: prevalence and risk factors.Frontiers in public health · 2026Article
- Impact of extended prophylactic antibiotic administration on surgical site infections: A multicenter real-world data study.Surgery today · 2025Article
- An Antibiotic Stewardship Program in Pancreatic Surgery.JAMA network open · 2025Observational
- Article
- Positive Intraoperative Bile Culture and Antibiotic Resistance Increase the Risk of Pancreatic Fistula in Patients After Pancreatoduodenectomy.Journal of clinical medicine · 2025Article
- Goal-oriented preoperative biliary drainage is more precise and conducive to seize the opportunity for pancreaticoduodenectomy.World journal of surgical oncology · 2024Article
- Article
- How I do it. Pancreatojejunostomy: surgical tips to mitigate the severity of postoperative pancreatic fistulas after open or minimally invasive pancreatoduodenectomy.Updates in surgery · 2024Article
- Article
- Non-Surgical Interventions for the Prevention of Clinically Relevant Postoperative Pancreatic Fistula-A Narrative Review.Cancers · 2023Review
- Antibiotic prophylaxis after 48 h postoperatively are not associated with decreased surgical site infections and other healthcare associated infections in pancreatic surgery patients: a retrospective cohort study.Antimicrobial resistance and infection control · 2023Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies have reported conflicting results of prolonged antibiotic prophylaxis on infectious complications after pancreatoduodenectomy. This study evaluated the effect of prolonged antibiotics on surgical-site infections (SSIs) after pancreatoduodenectomy.
methodsA systematic review and meta-analysis was undertaken of SSIs in patients with perioperative (within 24 h) versus prolonged antibiotic (over 24 h) prophylaxis after pancreatoduodenectomy. SSIs were classified as organ/space infections or superficial SSI within 30 days after surgery. ORs were calculated using a Mantel-Haenszel fixed-effect model.
resultsTen studies were included in the qualitative analysis, of which 8 reporting on 1170 patients were included in the quantitative analysis. The duration of prolonged antibiotic prophylaxis varied between 2 and 10 days after surgery. Four studies reporting on 782 patients showed comparable organ/space infection rates in patients receiving perioperative and prolonged antibiotics (OR 1.35, 95 per cent c.i. 0.94 to 1.93). However, among patients with preoperative biliary drainage (5 studies reporting on 577 patients), organ/space infection rates were lower with prolonged compared with perioperative antibiotics (OR 2.09, 1.43 to 3.07). Three studies (633 patients) demonstrated comparable superficial SSI rates between patients receiving perioperative versus prolonged prophylaxis (OR 1.54, 0.97 to 2.44), as well as in patients with preoperative biliary drainage in 4 studies reporting on 431 patients (OR 1.60, 0.89 to 2.88).
conclusionProlonged antibiotic prophylaxis is associated with fewer organ/space infection in patients who undergo preoperative biliary drainage. However, the optimal duration of antibiotic prophylaxis after pancreatoduodenectomy remains to be determined and warrants confirmation in an RCT.
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